ORMDL1 and ZFYVE27

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ORMDL1	ZFYVE27
Description		ORMDL sphingolipid biosynthesis regulator 1	zinc finger FYVE-type containing 27
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Serine Palmitoyltransferase Complex	Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endomembrane System Membrane Axon Dendrite Growth Cone Membrane Cell Projection Recycling Endosome Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Sphingolipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Biosynthetic Process Sphingolipid Biosynthetic Process Myelination Motor Behavior Regulation Of Sphingolipid Biosynthetic Process Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Regulation Of Ceramide Biosynthetic Process	Vesicle-mediated Transport Neuron Projection Development Positive Regulation Of Axon Extension Neurotrophin TRK Receptor Signaling Pathway Endoplasmic Reticulum Tubular Network Formation Protein Localization To Plasma Membrane
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Bilirubin levels ( 20639394) Ferritin levels ( 25162662)
Interacting Genes		42 interacting genes: APP AQP6 ARL13B ASGR2 BIK CD79A COQ9 CPLX4 CREB3 CREB3L1 EBAG9 EBP EHHADH ERGIC3 FAM209A GPR152 HSD17B11 KCNK4 LMNA LNX1 MTIF3 PCNX2 PGRMC2 REEP4 SAR1A SCN3B SLC10A1 SLC10A6 SLC18A1 SLC30A8 SLC35H1 SLC71A2 STOM TIMMDC1 TLCD4 TMEM143 TMEM14B TMEM35A TMEM52B VMA21 ZDHHC15 ZFYVE27	18 interacting genes: APP GIMAP1 GIMAP5 IER3IP1 ORMDL1 OTOP3 PIP4P2 SACM1L SEC22A SLC30A8 SLC66A2 STX7 TMEM128 TMEM14C TMEM243 TMEM65 TSPAN2 YIF1A
Entrez ID		94101	118813
HPRD ID		15092	15735
Ensembl ID		ENSG00000128699	ENSG00000155256
Uniprot IDs		Q9P0S3	A0A0S2Z5V0 A0A0S2Z627 B7Z6J9 Q5T4F4
PDB IDs			1X4U
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Protein Binding Bile Acid:sodium Symporter Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Membrane	Membrane Microglia Development Intracellular Transport Vesicle-mediated Transport Insulin Metabolic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Phosphatidylinositol Dephosphorylation Cellular Localization Endoplasmic Reticulum Establishment Of Localization In Cell SNAP Receptor Activity Golgi Membrane Endoplasmic Reticulum Membrane COPII-coated ER To Golgi Transport Vesicle Phospholipid Dephosphorylation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Endosome Amylin Binding Positive Regulation Of Toll Signaling Pathway
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