ORMDL1 and KCNK4

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ORMDL1	KCNK4
Name		ORMDL sphingolipid biosynthesis regulator 1	potassium two pore domain channel subfamily K member 4
Structure		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Serine Palmitoyltransferase Complex	Plasma Membrane Membrane Axon Node Of Ranvier Monoatomic Ion Channel Complex Potassium Channel Complex Cell Projection
	Molecular Function	Protein Binding	Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity Identical Protein Binding Metal Ion Binding Temperature-gated Cation Channel Activity Mechanosensitive Potassium Channel Activity
	Biological Process	Sphingolipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Biosynthetic Process Sphingolipid Biosynthetic Process Myelination Motor Behavior Regulation Of Sphingolipid Biosynthetic Process Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Regulation Of Ceramide Biosynthetic Process	Monoatomic Ion Transport Potassium Ion Transport Memory Response To Mechanical Stimulus Neuronal Action Potential Sensory Perception Of Pain Monoatomic Ion Transmembrane Transport Sensory Perception Of Temperature Stimulus Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Cellular Response To Mechanical Stimulus Cellular Response To Fatty Acid Cellular Response To Acidic PH Cellular Response To Alkaline PH Cellular Response To Temperature Stimulus Potassium Ion Transmembrane Transport Cellular Response To Arachidonate Response To Ultrasound
Pathways		Sphingolipid de novo biosynthesis	TWIK related potassium channel (TREK) Phase 4 - resting membrane potential
GWAS		Bilirubin levels ( 20639394 ) Ferritin levels ( 25162662 )	Crohn's disease ( 28067908 ) Sarcoidosis ( 22837380 ) Vitiligo ( 27723757 )
Novel Interactors		None recorded	1 novel interactors: NRG1
Interacting Genes		42 interacting genes: APP AQP6 ARL13B ASGR2 BIK CD79A COQ9 CPLX4 CREB3 CREB3L1 EBAG9 EBP EHHADH ERGIC3 FAM209A GPR152 HSD17B11 KCNK4 LMNA LNX1 MTIF3 PCNX2 PGRMC2 REEP4 SAR1A SCN3B SLC10A1 SLC10A6 SLC18A1 SLC30A8 SLC35H1 SLC71A2 STOM TIMMDC1 TLCD4 TMEM143 TMEM14B TMEM35A TMEM52B VMA21 ZDHHC15 ZFYVE27	3 interacting genes: DIDO1 ORMDL1 RPL14
Entrez ID		94101	50801
HPRD ID		15092	12037
Ensembl ID		ENSG00000128699	ENSG00000182450
Uniprot IDs		Q9P0S3	Q2YDA1 Q9NYG8
PDB IDs		Not available	3UM7 4I9W 4RUE 4RUF 4WFE 4WFF 4WFG 4WFH 7LJ4 7LJ5 7LJA 7LJB
GO Terms Enriched among Interactors		Membrane Endoplasmic Reticulum Protein Binding Bile Acid:sodium Symporter Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Membrane	Activation Of Protein Kinase B Activity Ventricular Cardiac Muscle Cell Differentiation ErbB-3 Class Receptor Binding Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Protein Autophosphorylation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB2-ERBB4 Signaling Pathway Endocardial Cell Differentiation ERBB4 Signaling Pathway Nickel Cation Binding ERBB4-ERBB4 Signaling Pathway Intracellular Sphingolipid Homeostasis Serine Palmitoyltransferase Complex Negative Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Cardiac Muscle Cell Myoblast Differentiation Sphingomyelin Biosynthetic Process Ventricular Trabecula Myocardium Morphogenesis Cardioblast Differentiation Regulation Of Protein Autophosphorylation Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Protein Tyrosine Kinase Activator Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Large Ribosomal Subunit Sphingomyelin Metabolic Process Regulation Of Membrane Lipid Metabolic Process Heart Trabecula Morphogenesis