ORMDL1 and PCNX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ORMDL1	PCNX2
Description		ORMDL sphingolipid biosynthesis regulator 1	pecanex 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Serine Palmitoyltransferase Complex	Cellular_component Membrane
	Molecular Function	Protein Binding	Molecular_function Protein Binding
	Biological Process	Sphingolipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Biosynthetic Process Sphingolipid Biosynthetic Process Myelination Motor Behavior Regulation Of Sphingolipid Biosynthetic Process Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Regulation Of Ceramide Biosynthetic Process	Biological_process
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Bilirubin levels ( 20639394) Ferritin levels ( 25162662)
Interacting Genes		42 interacting genes: APP AQP6 ARL13B ASGR2 BIK CD79A COQ9 CPLX4 CREB3 CREB3L1 EBAG9 EBP EHHADH ERGIC3 FAM209A GPR152 HSD17B11 KCNK4 LMNA LNX1 MTIF3 PCNX2 PGRMC2 REEP4 SAR1A SCN3B SLC10A1 SLC10A6 SLC18A1 SLC30A8 SLC35H1 SLC71A2 STOM TIMMDC1 TLCD4 TMEM143 TMEM14B TMEM35A TMEM52B VMA21 ZDHHC15 ZFYVE27	3 interacting genes: ABHD5 ORMDL1 SLC30A2
Entrez ID		94101	80003
HPRD ID		15092	15108
Ensembl ID		ENSG00000128699	ENSG00000135749
Uniprot IDs		Q9P0S3	A6NKB5 B3KNZ5
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Protein Binding Bile Acid:sodium Symporter Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Membrane	Zinc Ion Import Into Zymogen Granule Chemical Homeostasis Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Homeostatic Process Zinc Export Across Plasma Membrane Phospholipid Biosynthetic Process Lipid Homeostasis Negative Regulation Of Triglyceride Storage Lipase Activator Activity Zinc:proton Antiporter Activity Zinc Ion Import Into Lysosome Regulation Of Lipid Metabolic Process Phospholipid Metabolic Process Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Sphingolipid Biosynthetic Process Serine Palmitoyltransferase Complex Vacuolar Transmembrane Transport Positive Regulation Of Triglyceride Catabolic Process Secretory Vesicle Zinc Ion Import Into Organelle Lysophosphatidic Acid Acyltransferase Activity Sphingomyelin Biosynthetic Process Zymogen Granule Membrane Intracellular Chemical Homeostasis Monoatomic Cation Transmembrane Transporter Activity 1-acylglycerol-3-phosphate O-acyltransferase Activity Lipid Biosynthetic Process Organophosphate Biosynthetic Process Regulation Of Ceramide Biosynthetic Process Regulation Of Sphingolipid Biosynthetic Process Triacylglycerol Lipase Activity Sphingomyelin Metabolic Process Regulation Of Membrane Lipid Metabolic Process Negative Regulation Of Lipid Storage Positive Regulation Of Triglyceride Metabolic Process Cellular Homeostasis Zinc Ion Transmembrane Transporter Activity Zinc Ion Transport Zinc Ion Transmembrane Transport Positive Regulation Of Lipid Catabolic Process Phosphatidic Acid Biosynthetic Process Motor Behavior Intracellular Zinc Ion Homeostasis Phosphatidic Acid Metabolic Process Carboxylic Ester Hydrolase Activity Regulation Of Triglyceride Metabolic Process Response To Zinc Ion Regulation Of Lipid Storage
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