SYAP1 and MIP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SYAP1	MIP
Description		synapse associated protein 1	major intrinsic protein of lens fiber
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Axon Dendrite Growth Cone Presynaptic Membrane Cell Projection Perikaryon Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane Membrane Apical Plasma Membrane Anchoring Junction
	Molecular Function	Protein Binding	Structural Constituent Of Eye Lens Protein Binding Calmodulin Binding Water Channel Activity Channel Activity Cell Adhesion Mediator Activity
	Biological Process	Cell Differentiation Cellular Response To Insulin Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus TORC2 Signaling Positive Regulation Of Fat Cell Differentiation Regulation Of Short-term Neuronal Synaptic Plasticity Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Cellular Response To Insulin-like Growth Factor Stimulus	Lens Development In Camera-type Eye Water Transport Visual Perception Homotypic Cell-cell Adhesion Maintenance Of Lens Transparency Transmembrane Transport Gap Junction-mediated Intercellular Transport
Pathways			Passive transport by Aquaporins
Drugs			B-nonylglucoside
Diseases
GWAS			Axial length ( 24144296) Lipoprotein (a) levels ( 33730874) Serum metabolite levels ( 33031748)
Interacting Genes		7 interacting genes: ADIPOQ MIP OGT POT1 THRA TNFRSF10C ZFPL1	48 interacting genes: AQP6 AQP9 ATP6V0B CALM1 CD40 CISD2 CLDN5 CRYAA CRYAB CRYBB2 CRYGC ERGIC3 ERVFRD-1 FAM209A FCGR2A FOXA2 GJA3 GJA8 GJB5 GOLM1 GPX8 KCNJ6 LHFPL5 LMNA LRRC4C MFF MGST3 MRM3 MRPS18B MUC1 PDZK1IP1 PRKACA RELL2 SAR1A SGPL1 SLC14A1 SLC18A1 SSMEM1 STX1A STX2 SYAP1 SYT1 SYT2 TMEM139 TMEM154 TMEM52B TMX2 ZFPL1
Entrez ID		94056	4284
HPRD ID		06733	01098
Ensembl ID		ENSG00000169895	ENSG00000135517
Uniprot IDs		Q96A49	P30301
PDB IDs		1X3A
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cold-induced Thermogenesis Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cellular Component Organization Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of DNA Biosynthetic Process Regulation Of Lipid Metabolic Process Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Gluconeogenesis Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Renal Albumin Absorption Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Chromatin DNA Binding Regulation Of DNA Biosynthetic Process Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Regulation Of Programmed Cell Death Thyroid Hormone Receptor Signaling Pathway Female Courtship Behavior Macromolecule Biosynthetic Process Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Hormone-mediated Signaling Pathway Positive Regulation Of Female Receptivity Response To Monosaccharide Positive Regulation Of Lipid Metabolic Process Response To Glucose Response To Nutrient Regulation Of Glucose Metabolic Process Protein O-acetylglucosaminyltransferase Activity Circadian Rhythm Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Response To Linoleic Acid Detection Of Oxidative Stress Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Receptor Binding Negative Regulation Of DNA Metabolic Process Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Cholesterol Import Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Negative Regulation Of Nucleobase-containing Compound Metabolic Process Thyroid Hormone Binding	Membrane Lens Development In Camera-type Eye Structural Constituent Of Eye Lens Structural Molecule Activity Urea Channel Activity Gap Junction Channel Activity Connexin Complex SNARE Binding Synaptic Vesicle Membrane One-carbon Compound Transport Water Transport Gap Junction Calcium-dependent Protein Binding Organelle Localization By Membrane Tethering Clathrin-sculpted Monoamine Transport Vesicle Membrane Urea Transmembrane Transporter Activity Membrane Docking Camera-type Eye Development Gap Junction-mediated Intercellular Transport Fluid Transport Plasma Membrane Protein Binding Regulation Of Calcium Ion-dependent Exocytosis Chromaffin Granule Membrane Urea Transmembrane Transport Tubulin Complex Assembly Intercellular Transport Amine Transport Urea Transport Modulation Of Chemical Synaptic Transmission Eye Development Positive Regulation Of Catecholamine Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion Water Channel Activity Calcium Channel Inhibitor Activity Vesicle Docking Detection Of Calcium Ion Positive Regulation Of Calcium Ion-dependent Exocytosis Dense Core Granule Calcium Ion Sensor Activity Voltage-gated Potassium Channel Complex Sensory Organ Development Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Dendrite Extension Positive Regulation Of Vesicle Fusion Glutathione Peroxidase Activity
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