ELF1

Name	E74 like ETS transcription factor 1
Structure
Novel Interactors	1 novel interactors: CD27
Interactors	11 interactors: HMGA1 HOXC13 NFE2L2 NFKB1 NFYA NFYB NFYC RB1 REL RUNX1 SP1
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Cytokine Production Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways	RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 regulates transcription of genes involved in interleukin signaling
GWAS	Alanine aminotransferase levels ( 34315874 ) Aspartate aminotransferase levels ( 34315874 ) Cervical cancer ( 28806749 ) Crohn's disease ( 23266558 ) Eosinophil percentage of white cells ( 32888494 ) Height ( 31562340 ) Keratoconus ( 33649486 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lymphocyte count ( 27863252 32888494 ) Lymphocyte percentage of white cells ( 27863252 32888494 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Neutrophil percentage of white cells ( 32888494 27863252 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Spleen volume ( 34128465 ) Systemic lupus erythematosus ( 33272962 27399966 23273568 21044949 ) Total cholesterol levels ( 30275531 )
Entrez ID	1997
HPRD ID	01808
Ensembl ID	ENSG00000120690
Uniprot IDs	P32519
PDB IDs	8BZM
GO Terms Enriched among Interactors ?	Chromatin Transcription Cis-regulatory Region Binding Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein-DNA Complex Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific CCAAT-binding Factor Complex Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Transcription Regulator Complex Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Cellular Response To Peptide Hormone Stimulus DNA-binding Transcription Factor Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Sequence-specific DNA Binding Nucleoplasm Regulation Of Macromolecule Metabolic Process Response To Peptide Hormone Cellular Response To Angiotensin Cellular Response To Hormone Stimulus Regulation Of Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Developmental Process Response To Angiotensin Nucleus Positive Regulation Of Extracellular Matrix Organization Positive Regulation Of Amide Metabolic Process Positive Regulation Of Angiogenesis Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Vasculature Development Molecular Adaptor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Leukocyte Differentiation