OTOF and BTG3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		OTOF	BTG3
Description		otoferlin	BTG anti-proliferation factor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Presynaptic Membrane Cell Projection Synapse	Nucleus Cytoplasm
	Molecular Function	Calcium Ion Binding Metal Ion Binding	Protein Binding
	Biological Process	Sensory Perception Of Sound Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Secretion Membrane Fusion	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Mitotic Cell Cycle
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases		Deafness, autosomal recessive
GWAS		Metabolite levels (HVA) ( 23319000) Metabolite levels (HVA/MHPG ratio) ( 23319000) Periodontal microbiota ( 22699663)	Corpus callosum central volume ( 31530798) Feeling hurt ( 29500382)
Interacting Genes		4 interacting genes: BTG3 SRPK2 STK39 USP7	76 interacting genes: ADNP2 AFF4 AGAP2 AHCYL1 AIP ATXN1 BANP CACNA1A CCDC13 CCT7 CLTC CLU CNOT7 CNOT8 CNTN4 COPS5 CREBZF CRYL1 DCLK2 DDX18 DIS3L DMAP1 DNAJC14 DNAJC7 DYNC1H1 EIF3C EIF3F EPRS1 GLUL HECTD2 HECTD4 HIVEP2 HSP90AA1 HSP90AB1 KCNQ2 KDM3A KIF3A MAPK8IP3 MORF4L1 MRPL38 MTM1 MYCBP2 NISCH NRBP1 OGT OSBPL8 OTOF PAK1 PAX6 PLA2G3 PLEKHB1 PPP2R5E PPP3CA PRKAR1A QARS1 RANBP9 RBL2 RNF10 RSPH1 SEC23IP SETDB1 SMG5 SPARCL1 SRPK2 SYNE1 TAF1 TAF6 TRIM32 TSC2 TSPAN7 USP8 WAPL WDFY3 XPC ZNF532 ZNF592
Entrez ID		9381	10950
HPRD ID		04727	10415
Ensembl ID		ENSG00000115155	ENSG00000154640
Uniprot IDs		Q9HC10	Q14201 Q6IAU3
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptidyl-serine Phosphorylation Positive Regulation Of Sodium Ion Import Across Plasma Membrane Regulation Of RNA Splicing Phosphorylation Protein Serine Kinase Activity Nuclear Body Organization Protein Phosphorylation Protein Serine/threonine Kinase Activity R-loop Processing Nuclear Speck Organization Regulation Of Establishment Of Protein Localization To Chromosome Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Monoubiquitinated Protein Deubiquitination Negative Regulation Of Gluconeogenesis Regulation Of Establishment Of Protein Localization To Telomere DNA Alkylation Repair Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Telomere Capping Regulation Of Retrograde Transport, Endosome To Golgi Transcription-coupled Nucleotide-excision Repair K48-linked Deubiquitinase Activity Maintenance Of Lens Transparency Chloride Ion Homeostasis Positive Regulation Of Potassium Ion Import Across Plasma Membrane Negative Regulation Of Sodium Ion Transport Positive Regulation Of Lymphocyte Chemotaxis Hypotonic Response Cellular Hyperosmotic Response Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Transporter Activator Activity Ion Channel Regulator Activity Cellular Response To Potassium Ion Transporter Inhibitor Activity Cellular Hypotonic Response Cellular Response To Chemokine Negative Regulation Of Pancreatic Juice Secretion Intracellular Chloride Ion Homeostasis Positive Regulation Of Sodium Ion Transmembrane Transport Potassium Channel Inhibitor Activity Positive Regulation Of T Cell Chemotaxis Regulation Of T Cell Chemotaxis Regulation Of Potassium Ion Import Negative Regulation Of Sodium Ion Transmembrane Transport Response To Dietary Excess Response To Aldosterone MRNA Processing Response To Potassium Ion Monoatomic Anion Homeostasis Negative Regulation Of Potassium Ion Transmembrane Transport Peptidyl-threonine Phosphorylation	Cytosol Cytoplasm Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Establishment Of Localization In Cell Regulation Of Macromolecule Biosynthetic Process Eukaryotic Translation Initiation Factor 3 Complex Organelle Organization Nucleus Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Metabolic Process RNA Binding Cytoskeleton Organization Chaperone-mediated Protein Complex Assembly Protein Localization To Organelle Translation Initiation Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Unfolded Protein Binding Regulation Of Gene Expression Translation Intracellular Transport Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Intracellular Protein Localization Disordered Domain Specific Binding Regulation Of Cell Cycle Negative Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Telomerase Holoenzyme Complex Assembly Negative Regulation Of Catabolic Process CCR4-NOT Core Complex Chromatin Organization 3'-5'-RNA Exonuclease Activity Positive Regulation Of Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Gene Expression Nucleoplasm Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding ATP-dependent Protein Folding Chaperone
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