GRHPR and GLS2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GRHPR	GLS2
Description		glyoxylate and hydroxypyruvate reductase	glutaminase 2
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Peroxisomal Matrix Cytosol Extracellular Exosome Catalytic Complex	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding Hydroxypyruvate Reductase (NADH) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Hydroxypyruvate Reductase [NAD(P)H] Activity Glyoxylate Reductase (NADPH) Activity Carboxylic Acid Binding Protein Homodimerization Activity NADP Binding NAD Binding NADPH Binding Hydroxypyruvate Reductase (NADPH) Activity	Glutaminase Activity Protein Binding Hydrolase Activity
	Biological Process	Carboxylic Acid Metabolic Process Dicarboxylic Acid Metabolic Process Glyoxylate Metabolic Process	Amino Acid Metabolic Process Glutamate Biosynthetic Process Glutamine Metabolic Process L-glutamine Catabolic Process Regulation Of Apoptotic Process Reactive Oxygen Species Metabolic Process
Pathways		Glyoxylate metabolism and glycine degradation	Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism
Drugs			Glutamic acid
Diseases		Primary hyperoxaluria (HP)
GWAS		Bipolar disorder ( 31043756) C-reactive protein levels ( 33339817) Chronotype ( 30696823) Morning person ( 30696823) Severe bacterial meningitis ( 31092817)	Adverse response to drug ( 30420678) Axial length ( 24144296) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Fasting glucose ( 34059833) Glycine levels ( 30837465) Lipoprotein (a) levels ( 33730874) Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Serum metabolite levels ( 23093944 31636271) Serum metabolite levels (CMS) ( 31636271)
Interacting Genes		7 interacting genes: CDC7 FOS GLS2 LCOR LIG4 LSM1 PTH2R	14 interacting genes: CASK DLG1 DLG2 DLG3 DLG4 GRHPR PAG1 PATJ RALA RGS3 SLC26A4-AS1 SNTA1 TAX1BP3 XAF1
Entrez ID		9380	27165
HPRD ID		05052	05901
Ensembl ID		ENSG00000137106	ENSG00000135423
Uniprot IDs		A0A384N605 Q9UBQ7	A0A087X004 Q9UI32
PDB IDs		2GCG 2H1S 2Q50 2WWR	4BQM 5U0K 8SZL 8T0Z
Enriched GO Terms of Interacting Partners?		Response To Prolactin Conditioned Taste Aversion Medium-term Memory Cellular Response To Prolactin Establishment Of Integrated Proviral Latency DNA Ligase (ATP) Activity Stem Cell Population Maintenance DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Maintenance Of Cell Number Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Parathyroid Hormone Receptor Activity L-glutamine Catabolic Process Glutaminase Activity Cellular Response To Metal Ion Transcription Factor AP-1 Complex Cellular Response To Zinc Ion Starvation Nucleotide-excision Repair, DNA Gap Filling Glutamate Biosynthetic Process Lsm1-7-Pat1 Complex Response To Gravity DNA-dependent Protein Kinase-DNA Ligase 4 Complex Positive Regulation Of Nuclear Cell Cycle DNA Replication	Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Neuromuscular Junction Ionotropic Glutamate Receptor Binding GMP Kinase Activity Receptor Localization To Synapse Receptor Clustering GDP Metabolic Process Protein Localization To Synapse Establishment Or Maintenance Of Cell Polarity Synaptic Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Protein Localization To Cell Junction Kinase Binding GMP Metabolic Process Postsynaptic Density Membrane Adherens Junction Cell Junction Nucleoside Monophosphate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Juxtaparanode Region Of Axon Nucleoside Diphosphate Metabolic Process Basolateral Plasma Membrane Plasma Membrane Cellular Response To Potassium Ion Localization Within Membrane Purine Ribonucleotide Metabolic Process Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Protein Localization To Membrane Chemical Synaptic Transmission Response To Potassium Ion Bicellular Tight Junction Neuron Projection Trans-synaptic Signaling Synaptic Signaling Purine Nucleotide Metabolic Process AMPA Glutamate Receptor Complex Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Nucleotide Metabolic Process Regulation Of Sodium Ion Transmembrane Transport Intracellular Signal Transduction Protein Kinase Binding Purine-containing Compound Metabolic Process Cell-cell Junction Cell Adhesion P2Y1 Nucleotide Receptor Binding Hydroxypyruvate Reductase [NAD(P)H] Activity
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