GRHPR

Description		glyoxylate and hydroxypyruvate reductase
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Peroxisomal Matrix Cytosol Extracellular Exosome Catalytic Complex
	Molecular Function	Protein Binding Hydroxypyruvate Reductase (NADH) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Hydroxypyruvate Reductase [NAD(P)H] Activity Glyoxylate Reductase (NADPH) Activity Carboxylic Acid Binding Protein Homodimerization Activity NADP Binding NAD Binding NADPH Binding Hydroxypyruvate Reductase (NADPH) Activity
	Biological Process	Carboxylic Acid Metabolic Process Dicarboxylic Acid Metabolic Process Glyoxylate Metabolic Process
Pathways		Glyoxylate metabolism and glycine degradation
Drugs
Diseases		Primary hyperoxaluria (HP)
GWAS		Bipolar disorder ( 31043756) C-reactive protein levels ( 33339817) Chronotype ( 30696823) Morning person ( 30696823) Severe bacterial meningitis ( 31092817)
Interacting Genes		7 interacting genes: CDC7 FOS GLS2 LCOR LIG4 LSM1 PTH2R
Entrez ID		9380
HPRD ID		05052
Ensembl ID		ENSG00000137106
Uniprot IDs		A0A384N605 Q9UBQ7
PDB IDs		2GCG 2H1S 2Q50 2WWR
Enriched GO Terms of Interacting Partners?		Response To Prolactin Conditioned Taste Aversion Medium-term Memory Cellular Response To Prolactin Establishment Of Integrated Proviral Latency DNA Ligase (ATP) Activity Stem Cell Population Maintenance DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination Maintenance Of Cell Number Establishment Of Viral Latency DNA Ligase Activity DN2 Thymocyte Differentiation Parathyroid Hormone Receptor Activity L-glutamine Catabolic Process Glutaminase Activity Cellular Response To Metal Ion Transcription Factor AP-1 Complex Cellular Response To Zinc Ion Starvation Nucleotide-excision Repair, DNA Gap Filling Glutamate Biosynthetic Process Lsm1-7-Pat1 Complex Response To Gravity DNA-dependent Protein Kinase-DNA Ligase 4 Complex Positive Regulation Of Nuclear Cell Cycle DNA Replication
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