RAB33A and ATG16L1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)

		RAB33A	ATG16L1
Description		RAB33A, member RAS oncogene family	autophagy related 16 like 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endosome Golgi Apparatus Plasma Membrane Membrane	Autophagosome Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Autophagosome Cytosol Axoneme Endosome Membrane Membrane Axon Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Endolysosome Membrane Synapse Sperm Midpiece Glutamatergic Synapse Vacuole-isolation Membrane Contact Site
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity Metal Ion Binding	Protein Binding Ubiquitin-like Protein Transferase Activity Identical Protein Binding Protein-membrane Adaptor Activity GTPase Binding
	Biological Process	Autophagosome Assembly Antigen Processing And Presentation Rab Protein Signal Transduction	Autophagosome Assembly C-terminal Protein Lipidation Autophagy Positive Regulation Of Autophagy Protein Transport Macroautophagy Microautophagy Hippocampus Development Corpus Callosum Development Protein Localization To Phagophore Assembly Site Negative Stranded Viral RNA Replication Defense Response To Virus Xenophagy Axonal Transport Dendrite Arborization Negative Regulation Of Dendrite Extension
Pathways		TBC/RABGAPs RAB geranylgeranylation	Macroautophagy
Drugs
Diseases			Crohn's disease
GWAS		Bipolar disorder ( 31043756) Height ( 31562340)	Bilirubin levels ( 31319653 31801373 32084209) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17435756 17554300 18587394 20570966 21102463 22412388 22936669 23128233 28067908) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		15 interacting genes: ARL6IP1 ATG16L1 ATG16L2 CCDC136 KRT31 KRT34 LNX1 LRP2BP PSMF1 RABAC1 RTN3 RTN4 RUFY2 RUFY3 SIAH1	20 interacting genes: APP ATG5 C3 CRYAA CSNK2A1 CSNK2A2 DEDD2 GAN IFT20 NLRP6 NOD1 NOD2 OPTN RAB33A RAB33B RIPK2 SETD7 TRAF3IP3 WIPI2 ZFP36
Entrez ID		9363	55054
HPRD ID		02272	16498
Ensembl ID		ENSG00000134594	ENSG00000085978
Uniprot IDs		Q14088	E7EVC7 Q17RG0 Q676U5
PDB IDs			4GDK 4GDL 4NAW 4TQ0 5D7G 5NPV 5NPW 5NUV 5ZYX 7F69 7MU2 7W36 7XFR 8ZQG
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Tubular Network Formation Endoplasmic Reticulum Tubular Network Membrane Organization Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Tubular Network Organization Negative Stranded Viral RNA Replication Atg12-Atg5-Atg16 Complex Viral RNA Genome Replication Endoplasmic Reticulum Organization Endoplasmic Reticulum Tubular Network Phagophore Assembly Site Membrane Viral Genome Replication Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Organelle Organization GTPase Binding Supramolecular Fiber Organization Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Amyloid-beta Formation Negative Regulation Of Axonogenesis Vacuole-isolation Membrane Contact Site Negative Regulation Of Vasculogenesis Positive Regulation Of ERBB3 Signaling Pathway Cell Adhesion Involved In Sprouting Angiogenesis Structural Constituent Of Skin Epidermis Nervous System Development Positive Regulation Of Retrograde Axon Cargo Transport C-terminal Protein Lipidation Intermediate Filament Organization Cell Differentiation Regulation Of Amide Metabolic Process Regulation Of Axon Extension Autophagosome Regulation Of Developmental Growth Positive Regulation Of Protein Localization To Endoplasmic Reticulum Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Autophagosome Assembly Negative Regulation Of Developmental Growth Positive Regulation Of L-glutamate Import Across Plasma Membrane Negative Regulation Of Dendrite Extension Cell Migration Involved In Vasculogenesis Autophagosome Organization Regulation Of Endoplasmic Reticulum Tubular Network Organization Regulation Of Branching Morphogenesis Of A Nerve Intracellular Sphingolipid Homeostasis Central Nervous System Vasculogenesis Endoplasmic Reticulum Tubular Network Membrane Regulation Of Cell Growth Negative Regulation Of Neuron Projection Development	Autophagy Regulation Of Macroautophagy Response To Stress Positive Regulation Of Interleukin-1 Beta Production Regulation Of Autophagy Positive Regulation Of Catabolic Process Positive Regulation Of Interleukin-1 Production Regulation Of Cytokine Production Regulation Of Defense Response Macroautophagy Regulation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Autophagy Positive Regulation Of Xenophagy Cell Death Regulation Of Interleukin-1 Beta Production Positive Regulation Of Macroautophagy Cellular Response To Muramyl Dipeptide Protein-containing Complex Regulation Of Interleukin-1 Production Response To Bacterium Intracellular Signal Transduction CARD Domain Binding Signal Transduction Innate Immune Response Immune System Process Programmed Cell Death Regulation Of Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Stress-activated MAPK Cascade Defense Response To Bacterium Response To Muramyl Dipeptide Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cytokine Production Golgi Apparatus Phagophore Assembly Site Membrane Defense Response To Symbiont Defense Response To Other Organism P38MAPK Cascade Protein Kinase CK2 Complex Protein Localization To Golgi Apparatus Regulation Of Apoptotic Process Autophagosome Assembly Positive Regulation Of Interleukin-6 Production Regulation Of Programmed Cell Death Positive Regulation Of JNK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Autophagosome Organization Immune Response
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