TPTE2 and AATK

Number of citations of the paper that reports this interaction (PubMedID 28065597)
51

Data Source:
BioGRID (two hybrid)

		TPTE2	AATK
Description		transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	apoptosis associated tyrosine kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane	Cytoplasm Endomembrane System Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Monoatomic Ion Channel Activity Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Hydrolase Activity Phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport Transmembrane Transport	Brain Development Neuron Apoptotic Process
Pathways		Synthesis of PIPs at the Golgi membrane
Drugs
Diseases
GWAS		Liver fibrosis (total hepatic collagen content) ( 32953199)	Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) Beef consumption ( 32066663) Lymphocyte percentage of white cells ( 32888494) Neuroticism ( 29255261) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		5 interacting genes: AATK BRCA1 EPHA2 LMTK2 PTK7	41 interacting genes: BDKRB2 CDC14A CDC25B CDK5 DUSP1 DUSP14 DUSP29 DUSP5 DUSP6 DUSP9 ERBB2 EYA2 EYA4 ILKAP MTMR10 MTMR6 MTMR8 MTMR9 PPM1A PPM1B PPM1F PPM1K PPM1M PPP1CA PPP3CA PPP3CB PTEN PTPDC1 PTPN11 PTPN12 PTPN18 PTPN20 PTPN6 PTPN7 PTPRR SBF1 STK39 STYX TAB1 TEPSIN TPTE2
Entrez ID		93492	9625
HPRD ID		06003	05591
Ensembl ID		ENSG00000132958	ENSG00000181409
Uniprot IDs		Q6XPS3	H7C175 Q6ZMQ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Kinase Activity Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity Transferase Activity BRCA1-BARD1 Complex Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage ATP Binding Notochord Cell Development Kinase Activity Axial Mesoderm Formation Protein Tyrosine Kinase Activity Myosin VI Binding Blood Vessel Development Negative Regulation Of Lymphangiogenesis Notochord Formation Intrinsic Apoptotic Signaling Pathway BRCA1-B Complex Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol BRCA1-C Complex Response To Indole-3-methanol Notochord Morphogenesis Pericyte Cell Differentiation Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Centriole Replication Lens Fiber Cell Morphogenesis BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Endomembrane System Negative Regulation Of Centrosome Duplication Regulation Of Vasculature Development Regulation Of Angiogenesis Lateral Element Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gamma-tubulin Ring Complex Apoptotic Signaling Pathway DNA Strand Resection Involved In Replication Fork Processing DNA Repair Complex Random Inactivation Of X Chromosome Leading Edge Membrane Positive Regulation Of Bicellular Tight Junction Assembly Morphogenesis Of An Epithelium Ephrin Receptor Activity Lung-associated Mesenchyme Development Axon Guidance Receptor Activity Convergent Extension Neuronal Cell Body Protein Serine Kinase Activity Transferrin Transport Sex-chromosome Dosage Compensation	Phosphoprotein Phosphatase Activity Dephosphorylation Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Protein Serine/threonine Phosphatase Activity Hydrolase Activity Phosphate-containing Compound Metabolic Process Protein Tyrosine/serine/threonine Phosphatase Activity Protein Modification Process Peptidyl-tyrosine Dephosphorylation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Cytoplasm MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Negative Regulation Of Signaling Regulation Of Signal Transduction Cytosol Regulation Of Cell Communication Regulation Of Signaling Protein Metabolic Process Negative Regulation Of Cell Communication Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Phosphatase Activity Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of MAPK Cascade Phosphatidylinositol Dephosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Peptidyl-threonine Dephosphorylation Negative Regulation Of Intracellular Signal Transduction Phospholipid Dephosphorylation Macromolecule Metabolic Process Intracellular Signaling Cassette Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Intracellular Signal Transduction ERK1 And ERK2 Cascade Manganese Ion Binding Cerebellar Cortex Formation Peptidyl-serine Dephosphorylation Phosphatidylinositol Metabolic Process Phosphatidylinositol-3,5-bisphosphate Phosphatase Activity MAPK Cascade N-terminal Protein Myristoylation ErbB-3 Class Receptor Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Negative Regulation Of Transport Nucleoplasm
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