HAUS8 and NUP54

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HAUS8	NUP54
Description		HAUS augmin like complex subunit 8	nucleoporin 54
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GO Annotations	Cellular Component	Spindle Pole Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Nuclear Microtubule HAUS Complex Mitotic Spindle Microtubule	Nucleus Nuclear Envelope Nuclear Pore Membrane Nuclear Membrane Nuclear Pore Central Transport Channel
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding Structural Constituent Of Nuclear Pore
	Biological Process	Centrosome Cycle Regulation Of Microtubule Nucleation Spindle Assembly Cell Division	NLS-bearing Protein Import Into Nucleus Nucleocytoplasmic Transport Nuclear Pore Organization Protein Transport Protein Localization To Nuclear Inner Membrane MRNA Transport
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin concentration ( 32888494) Mosquito bite size ( 28199695) Selective IgA deficiency ( 27723758) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Age at first birth ( 34211149) Hippocampal volume ( 29274321)
Interacting Genes		14 interacting genes: APP C1orf216 CCHCR1 DEUP1 HAUS6 HSPB1 NME7 NRDE2 NTAQ1 NUP54 OGT TXN2 USHBP1 ZG16B	46 interacting genes: AGR2 AIRIM AP1B1 AP2B1 APC BPIFA1 C14orf119 C21orf91 CCDC85B CCHCR1 CDC23 CENPH DCTN3 DGCR6 EFHC1 EIF3F EXOC1 EXOC8 HAUS1 HAUS8 HGS IFT20 KPNA1 KPNB1 KRT15 KRT27 KRT33B NFKBID NR3C1 NUP62 NUTF2 OGT OIP5 PKNOX2 SMYD3 SOHLH1 SPG21 SSR1 TACC3 TCHP TEKT1 TEX12 TPM3 TRIM54 VPS37C ZWINT
Entrez ID		93323	53371
HPRD ID		11318	06352
Ensembl ID		ENSG00000131351	ENSG00000138750
Uniprot IDs		Q9BT25	A0A8Q3SHX2 A0A8Q3WLP2 Q7Z3B4
PDB IDs		7SQK	4JNU 4JNV 4JO7 4JO9 5IJN 5IJO 7N8R 7PER 7R5J 7R5K
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Cytoskeleton-dependent Intracellular Transport Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Microtubule-based Transport Transport Along Microtubule Amylin Binding Positive Regulation Of Toll Signaling Pathway Microtubule-based Process Negative Regulation Of Protein Kinase C Signaling Spindle Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Microtubule Nucleation Protein-N-terminal Glutamine Amidohydrolase Activity	Cytoskeleton Cytoskeleton-dependent Cytokinesis Centrosome Organelle Assembly Cell Division Regulation Of Microtubule Cytoskeleton Organization Spindle Organization Establishment Of Protein Localization Membrane Fission Microtubule-based Process Intracellular Protein Transport Nuclear Import Signal Receptor Activity Organelle Organization Protein Transport Mitotic Cytokinesis Cytosol Spindle Cellular Localization Chromosome Localization Spindle Pole Regulation Of Microtubule-based Process Nuclear Pore Protein Binding Nuclear Pore Central Transport Channel Membraneless Organelle Assembly Keratin Filament Mitotic Spindle Organization Positive Regulation Of Protein Localization To Centrosome Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Microtubule Polymerization Or Depolymerization Hsp90 Protein Binding Metaphase/anaphase Transition Of Cell Cycle HAUS Complex Regulation Of Sister Chromatid Segregation Vesicle Tethering Involved In Exocytosis Intracellular Protein Localization Mitotic Metaphase Chromosome Alignment Organelle Localization NLS-dependent Protein Nuclear Import Complex Centrosome Cycle Regulation Of Mitotic Nuclear Division Protein Import Into Nucleus Establishment Of Protein Localization To Organelle Intracellular Transport Protein Localization To Organelle Import Into Nucleus Clathrin Adaptor Complex Regulation Of Protein Localization To Centrosome Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Chromosome Segregation
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