GRAMD3 and NAPRT

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		GRAMD3	NAPRT
Gene Name		GRAM domain containing 3	nicotinate phosphoribosyltransferase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic Microtubule	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Extracellular Vesicular Exosome
	Molecular Function		Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity Nicotinate Phosphoribosyltransferase Activity Ligase Activity
	Biological Process		Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process Nicotinamide Metabolic Process Response To Oxidative Stress NAD Biosynthetic Process Nicotinate Nucleotide Salvage NAD Metabolic Process Small Molecule Metabolic Process
Pathways			Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Nicotinamide salvaging Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Nicotinate metabolism Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs
Diseases
GWAS		Cognitive performance ( 20125193) Diabetic retinopathy ( 21441570)
Protein-Protein Interactions		6 interactors: ABO FRMD8 GIMAP5 MORF4L2 NAPRT PAEP	5 interactors: CCDC57 EHMT2 GRAMD3 KRT40 RBPMS
Entrez ID		65983	93100
HPRD ID		11402	15161
Ensembl ID		ENSG00000155324	ENSG00000147813
Uniprot IDs		Q96HH9	Q6XQN6
PDB IDs
Enriched GO Terms of Interacting Partners?		Nicotinate Nucleotide Salvage Nicotinamide Metabolic Process Alkaloid Metabolic Process	DNA Methylation On Cytosine Within A CG Sequence Histone H3-K27 Methylation Peptidyl-lysine Dimethylation DNA Methylation On Cytosine Positive Regulation Of SMAD Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus Histone H3-K9 Methylation Synaptonemal Complex Assembly Synaptonemal Complex Organization Histone H3-K9 Modification
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