CYTH2 and PRRG2

		CYTH2	PRRG2
Description		cytohesin 2	proline rich and Gla domain 2
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Growth Cone Cell Projection Anchoring Junction	Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Inositol 1,4,5 Trisphosphate Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Endocytosis Actin Cytoskeleton Organization Regulation Of ARF Protein Signal Transduction	Proteolysis Blood Coagulation
Pathways		Intra-Golgi traffic
Drugs		Inositol 1,3,4,5-Tetrakisphosphate Formic acid 1D-myo-inositol 1,4,5-trisphosphate S,S-(2-Hydroxyethyl)Thiocysteine Brefeldin A
Diseases
GWAS		Abstraction and mental flexibility ( 31596458)	Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Iron status biomarkers (total iron binding capacity) ( 33536631) Red blood cell count ( 27863252 32888494) Schizophrenia ( 25056061 29483656 30285260)
Interacting Genes		30 interacting genes: ADORA2A ALDOA APC ARF1 ARF6 ARFGAP1 ARL4A ARL4D ARRB1 ARRB2 ATP6V0A1 ATP6V0A2 ATP6V0A4 CCDC120 CUX1 CYTIP DOCK1 GGA3 GNAQ IPCEF1 ITGB2 MAPK6 PIK3CA PNPLA2 PRKCA PRKCB PRKCG SNCA TCIRG1 TRIM23	8 interacting genes: CRK FAM221A FATE1 NEDD4 NEDD4L SGTA WWTR1 YAP1
Entrez ID		9266	5639
HPRD ID		03925	09189
Ensembl ID		ENSG00000105443	ENSG00000126460
Uniprot IDs		Q99418	O14669 Q8TAS3
PDB IDs		1PBV 1R8M 1R8Q 1R8S 1S9D 4JMI 4JMO 4JWL 4JXH 4L5M 4Z21	9BVP 9BVQ
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Proton-transporting V-type ATPase, V0 Domain Vacuolar Proton-transporting V-type ATPase, V0 Domain Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Biological Quality Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Proton-transporting V-type ATPase Complex Regulation Of Vesicle-mediated Transport Proton-transporting ATPase Activity, Rotational Mechanism Vacuolar Acidification Endocytosis Positive Regulation Of Protein Localization Intracellular Protein Localization Regulation Of Endocytosis Cellular Homeostasis Membrane Protein Transport Intracellular PH Reduction Angiotensin Receptor Binding Histone H3T6 Kinase Activity Regulation Of Protein Localization Diacylglycerol-dependent Serine/threonine Kinase Activity Lysosomal Membrane Intracellular Chemical Homeostasis Regulation Of Secretion By Cell Receptor Internalization Establishment Of Protein Localization Import Into Cell Endosome Membrane Regulation Of Transport Regulation Of Secretion Phagocytic Vesicle Membrane Positive Regulation Of Secretion By Cell ATPase Binding Regulation Of Intracellular PH Regulation Of Neurotransmitter Secretion Chemical Homeostasis Negative Regulation Of Dopamine Metabolic Process Protein Kinase C Signaling Regulation Of Cellular PH Monoatomic Cation Homeostasis Positive Regulation Of Secretion GTPase Activity Regulation Of Exocytosis Apoptotic Process Monoatomic Ion Homeostasis Phagocytosis Regulation Of PH Negative Regulation Of Catecholamine Metabolic Process	Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Sodium Channel Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Potassium Channel Inhibitor Activity Regulation Of Nephron Tubule Epithelial Cell Differentiation Regulation Of Dendrite Development Negative Regulation Of Sodium Ion Transport Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Proline-rich Region Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Receptor Catabolic Process Negative Regulation Of Potassium Ion Transmembrane Transport Bicellular Tight Junction Hippo Signaling Positive Regulation Of Cell Growth Negative Regulation Of Potassium Ion Transport Heart Process Regulation Of Neuron Projection Development Neuromuscular Junction Development Plasma Membrane Bounded Cell Projection Organization Neuron Projection Development Plasma Membrane Positive Regulation Of Protein Catabolic Process Receptor Metabolic Process Formation Of Structure Involved In A Symbiotic Process Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Meiotic Spindle Elongation Enterocyte Differentiation Protein Monoubiquitination Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Growth Macromolecule Catabolic Process Mesenchyme Development Regulation Of Growth Regulation Of Dendrite Morphogenesis Helper T Cell Diapedesis Regulation Of Lymphocyte Migration Protein Phosphorylated Amino Acid Binding Cell Projection Organization Response To Cholecystokinin Regulation Of Developmental Process Receptor Internalization Channel Inhibitor Activity Negative Regulation Of Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Meiotic Cell Cycle Process Involved In Oocyte Maturation
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