GCM2 and DOK3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GCM2	DOK3
Description		glial cells missing transcription factor 2	docking protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytoplasm Plasma Membrane Membrane Secretory Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Intracellular Calcium Ion Homeostasis Intracellular Phosphate Ion Homeostasis Gliogenesis Positive Regulation Of Transcription By RNA Polymerase II Parathyroid Gland Development	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Menarche and menopause (age at onset) ( 19448621) Metabolite levels ( 23823483) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261)	Coronary artery disease ( 29212778) Inflammatory bowel disease ( 23128233) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		34 interacting genes: CEACAM6 CRX DOK3 ECM1 FHL3 GPSM1 GSC2 HOXA1 HSF2BP HSFY1 HSFY2 JMJD7 KRTAP6-2 KRTAP7-1 KRTAP8-1 LASP1 LHX3 MEOX2 MYOZ3 PAX6 PAX8 PLEKHG4 POU6F2 RBPMS RUSC1 SSBP1 TBX19 TOX3 TRAF1 USP54 WWOX YPEL3 ZMIZ2 ZNF34	31 interacting genes: A1CF ABL1 ANKS1A APPL1 APPL2 COX5B CRK CSK DOK1 DOK2 DOK5 DTX2 FYN GCM2 HOXA1 INPP5D LCK LYN MDFI PLEKHA3 PPIH PRKAB2 RBPMS RET RIN3 SHC3 SHE SPAG8 STAT3 TNS2 TRAF1
Entrez ID		9247	79930
HPRD ID		04758	16834
Ensembl ID		ENSG00000124827	ENSG00000146094
Uniprot IDs		O75603	A0A6M4C8X9 D6RAM3 Q7L591
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Sequence-specific Double-stranded DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process DNA Binding Sequence-specific DNA Binding Pituitary Gland Development Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Inner Ear Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Fate Specification Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process SMAD Protein Signal Transduction	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Ephrin Receptor Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Protein Tyrosine Kinase Activity Antigen Receptor-mediated Signaling Pathway Fc-gamma Receptor Signaling Pathway Signal Transduction T Cell Costimulation T Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Response To Hepatocyte Growth Factor Positive Regulation Of Macropinocytosis Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Protein Localization To Membrane Regulation Of MAPK Cascade Regulation Of Endocytosis CD8 Receptor Binding Positive Regulation Of Cell Adhesion Intracellular Signal Transduction Regulation Of Immune Response Cytosol Positive Regulation Of Lymphocyte Activation Regulation Of Phagocytosis Identical Protein Binding Regulation Of Toll-like Receptor 4 Signaling Pathway Macropinosome Immune Response-activating Signaling Pathway Negative Regulation Of Immune System Process Cytoplasm Regulation Of Cell Migration Regulation Of Vesicle-mediated Transport Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway SH2 Domain Binding Leukocyte Migration Regulation Of Immune System Process Regulation Of Cell Motility Positive Regulation Of Cell Activation Positive Regulation Of Pinocytosis Regulation Of Signal Transduction Regulation Of Locomotion
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