MSC and TCF12

Number of citations of the paper that reports this interaction (PubMedID 9584154)
81

Data Source:
HPRD (two hybrid)

		MSC	TCF12
Description		musculin	transcription factor 12
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding BHLH Transcription Factor Binding SMAD Binding Protein Heterodimerization Activity Protein Dimerization Activity E-box Binding HMG Box Domain Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cardiac Conduction System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Branchiomeric Skeletal Muscle Development Roof Of Mouth Development Diaphragm Development Cellular Response To Leukemia Inhibitory Factor	Regulation Of Transcription By RNA Polymerase II Immune Response Nervous System Development Muscle Organ Development Gene Expression Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Response To Gonadotropin-releasing Hormone
Pathways			Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription NGF-stimulated transcription Negative Regulation of CDH1 Gene Transcription TGFBR3 expression
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 30395268) Alanine aminotransferase levels ( 33547301) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Aspartate aminotransferase levels ( 33547301) Depression in smokers ( 30219690) Homeostasis model assessment of insulin resistance in less-fat diet ( 30327367) Homeostasis model assessment of insulin resistance x saturated fatty acids interaction ( 30327367) Late-onset myasthenia gravis ( 26562150) Optic disc size ( 31809533) QT interval ( 29213071) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein B levels ( 32203549) Body mass index ( 28892062) Glaucoma (primary open-angle) ( 29891935 33627673) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Male-pattern baldness ( 28196072) Mean platelet volume ( 27863252 32888494) Triglyceride levels ( 32154731) Type 2 diabetes ( 30297969)
Interacting Genes		8 interacting genes: EWSR1 GORASP2 ID2 LNX1 PBX2 TCF12 TCF3 TCF4	68 interacting genes: AIRIM ARL16 ARMC8 ASCL4 BMERB1 BMF CDKN2C CFAP206 CKS1B CLCNKA CRCP CREBBP DDX6 DGCR6 EDRF1 EP300 EXOC8 FRMD6 GRB7 HAND1 HOPX ID1 ID2 ID3 LAMTOR5 LNX1 LYSMD1 MAPKBP1 MLLT6 MORN4 MSC MYF6 MYO15B NAGK NEK6 NEUROD1 NEUROG1 NGLY1 NHLH2 OLIG3 OSGIN1 PIN1 PRKAB2 PRSS23 PSMA1 PTF1A QARS1 RBM8A RNASEL RUNX1T1 SOX10 SOX8 SPG21 SRI STAT5A STK16 TAF4 TAL2 TBC1D21 TBP TCF21 TCF3 TMEM132D TRIM72 TSNAX VPS28 WTAP ZNF688
Entrez ID		9242	6938
HPRD ID		04694	02725
Ensembl ID		ENSG00000178860	ENSG00000140262
Uniprot IDs		O60682	F5GY10 Q99081
PDB IDs			2KNH 4JOL
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity Regulation Of Neuron Differentiation Transcription Regulator Complex E-box Binding Positive Regulation Of Neuron Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nervous System Development BHLH Transcription Factor Binding DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Euchromatin Positive Regulation Of DNA-templated Transcription Positive Regulation Of Cell Differentiation Protein Heterodimerization Activity Cellular Developmental Process Positive Regulation Of RNA Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process System Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Regulation Of RNA Metabolic Process B Cell Differentiation Endodermal Digestive Tract Morphogenesis Developmental Process Thigmotaxis Beta-catenin-TCF7L2 Complex Vitamin D Response Element Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Dopaminergic Neuron Differentiation Bundle Of His Development Regulation Of B Cell Activation Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Cell Differentiation Positive Regulation Of Developmental Process Positive Regulation Of Transcription By RNA Polymerase II TFIIB-class Transcription Factor Binding RNA Polymerase II Transcription Regulator Complex Regulation Of Transcription By RNA Polymerase II Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process B Cell Lineage Commitment Negative Regulation Of B Cell Differentiation Positive Regulation Of Biosynthetic Process Regulation Of DNA-binding Transcription Factor Activity Enucleate Erythrocyte Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Protein Dimerization Activity Chromatin DNA-binding Transcription Factor Binding E-box Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Cell Fate Commitment Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Animal Organ Development Regulation Of Macromolecule Biosynthetic Process Neuron Differentiation BHLH Transcription Factor Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone H3K27 Acetyltransferase Activity Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Biosynthetic Process Nucleus Regulation Of Metabolic Process RNA Polymerase II Transcription Regulator Complex Striated Muscle Tissue Development Transcription Regulator Inhibitor Activity Nucleoplasm Regulation Of Macromolecule Metabolic Process Tau Protein Binding Oligodendrocyte Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Thigmotaxis Branchiomeric Skeletal Muscle Development Muscle Tissue Development Cytoplasm Negative Regulation Of Macromolecule Biosynthetic Process Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Developmental Process
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