MSC and TCF3

Number of citations of the paper that reports this interaction (PubMedID 9584154)
81

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		MSC	TCF3
Description		musculin	transcription factor 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Protein-containing Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Vitamin D Response Element Binding E-box Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cardiac Conduction System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Branchiomeric Skeletal Muscle Development Roof Of Mouth Development Diaphragm Development Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II B Cell Lineage Commitment Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Differentiation B Cell Differentiation Positive Regulation Of B Cell Proliferation Immunoglobulin V(D)J Recombination Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs Negative Regulation of CDH1 Gene Transcription TGFBR3 expression
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS		Adolescent idiopathic scoliosis ( 30395268) Alanine aminotransferase levels ( 33547301) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Aspartate aminotransferase levels ( 33547301) Depression in smokers ( 30219690) Homeostasis model assessment of insulin resistance in less-fat diet ( 30327367) Homeostasis model assessment of insulin resistance x saturated fatty acids interaction ( 30327367) Late-onset myasthenia gravis ( 26562150) Optic disc size ( 31809533) QT interval ( 29213071) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)	Hodgkin's lymphoma ( 24920014 29196614) Monocyte count ( 32888494) Objective response to lithium treatment ( 26503763) Triglyceride levels ( 34074324)
Interacting Genes		8 interacting genes: EWSR1 GORASP2 ID2 LNX1 PBX2 TCF12 TCF3 TCF4	66 interacting genes: AEBP1 ASCL3 AURKA BHLHA15 BHLHE40 CALM1 CALM3 CBFA2T3 CREBBP CTNNB1 DACH1 DAXX ELK3 EP300 FERD3L GLIS1 HAND1 HAND2 HOXA1 ID1 ID2 ID3 KAT2A KAT2B LMX1A LMX1B LYL1 MAPK1 MAPK3 MAPKAPK2 MAPKAPK3 MDFI MEN1 MSC MYF5 MYF6 MYOD1 MYOG NEDD9 NEUROD1 NHLH1 NSD3 PARP1 PDX1 PSMD4 PSMD9 RALGAPA1 RPL37 RUNX1T1 SCX SKP2 SRF SUPT3H TADA2A TAL1 TAL2 TCAF1 TCF12 TCF21 TCF4 TFPT TLE1 TRRAP TWIST1 UBE2I USF1
Entrez ID		9242	6929
HPRD ID		04694	00918
Ensembl ID		ENSG00000178860	ENSG00000071564
Uniprot IDs		O60682	P15923
PDB IDs			2MH0 2YPA 2YPB 3U5V 6MGN
Enriched GO Terms of Interacting Partners?		Protein Dimerization Activity Regulation Of Neuron Differentiation Transcription Regulator Complex E-box Binding Positive Regulation Of Neuron Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nervous System Development BHLH Transcription Factor Binding DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Euchromatin Positive Regulation Of DNA-templated Transcription Positive Regulation Of Cell Differentiation Protein Heterodimerization Activity Cellular Developmental Process Positive Regulation Of RNA Metabolic Process Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process System Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Regulation Of RNA Metabolic Process B Cell Differentiation Endodermal Digestive Tract Morphogenesis Developmental Process Thigmotaxis Beta-catenin-TCF7L2 Complex Vitamin D Response Element Binding Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Dopaminergic Neuron Differentiation Bundle Of His Development Regulation Of B Cell Activation Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Cell Differentiation Positive Regulation Of Developmental Process Positive Regulation Of Transcription By RNA Polymerase II TFIIB-class Transcription Factor Binding RNA Polymerase II Transcription Regulator Complex Regulation Of Transcription By RNA Polymerase II Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process B Cell Lineage Commitment Negative Regulation Of B Cell Differentiation Positive Regulation Of Biosynthetic Process Regulation Of DNA-binding Transcription Factor Activity Enucleate Erythrocyte Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Protein Dimerization Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Nucleus Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process E-box Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process DNA Binding BHLH Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoplasm Sequence-specific Double-stranded DNA Binding Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Negative Regulation Of Metabolic Process Cell Differentiation Animal Organ Development RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Developmental Process Animal Organ Morphogenesis Regulation Of Developmental Process Embryonic Morphogenesis
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