Wiki-Pi
About
Search
People
Updates
Search
ANAPC4 and UBE2S
Number of citations of the paper that reports this interaction (PubMedID
25306923
)
49
Data Source:
BioGRID
(pull down)
ANAPC4
UBE2S
Description
anaphase promoting complex subunit 4
ubiquitin conjugating enzyme E2 S
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Nuclear Periphery
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Protein Phosphatase Binding
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Anaphase-promoting Complex Binding
Transferase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Regulation Of Mitotic Cell Cycle
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Cell Division
Regulation Of Meiotic Cell Cycle
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein Branched Polyubiquitination
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Exit From Mitosis
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Protein K29-linked Ubiquitination
Protein Modification Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K27-linked Ubiquitination
Cell Division
Protein K63-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein K6-linked Ubiquitination
Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
Assembly of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
Assembly of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Adult body size (
32376654
)
Age at first sexual intercourse (
34211149
)
Body mass index (
29273807
)
Body size at age 10 (
32376654
)
General cognitive ability (
29844566
)
Heel bone mineral density (
30598549
)
Intelligence (MTAG) (
29326435
)
Logical memory (immediate recall) in normal cognition (
29274321
)
Multisite chronic pain (
31194737
)
Waist circumference adjusted for body mass index (
34021172
)
Weight (
20966902
)
Interacting Genes
5 interacting genes:
CCNA1
MAD2L1BP
PTTG1
UBE2I
UBE2S
33 interacting genes:
AKT1
ANAPC1
ANAPC11
ANAPC4
ANAPC5
ANAPC7
APP
ATXN3
BIRC2
CDC16
CDC20
CDC23
CDC27
CYLD
HECTD3
HERC1
LINC00839
MDM2
NFKBIA
OTUB1
OTUD7B
PRKN
RBCK1
STAMBP
UBA1
UBA6
UBB
UBC
UCHL3
USP2
USP21
USP5
USP7
Entrez ID
29945
27338
HPRD ID
09505
15603
Ensembl ID
ENSG00000053900
ENSG00000108106
Uniprot IDs
B3KN47
Q9UJX5
Q16763
PDB IDs
4UI9
5A31
5BPW
5G04
5G05
5KHR
5KHU
5L9T
5L9U
5LCW
6Q6G
6Q6H
6TLJ
6TM5
6TNT
8PKP
8TAR
8TAU
9GAW
1ZDN
5BNB
5L9T
6QH3
6QHK
6S96
6S98
7AHF
8TAU
Enriched GO Terms of Interacting Partners
?
Cell Division
SUMO Conjugating Enzyme Activity
O-phosphoseryl-tRNA(Sec) Selenium Transferase Activity
Conversion Of Seryl-tRNAsec To Selenocys-tRNAsec
Cyclin A1-CDK1 Complex
Cyclin A1-CDK2 Complex
RING-like Zinc Finger Domain Binding
Chromosome Segregation
SUMO Ligase Complex
Small Protein Activating Enzyme Binding
HLH Domain Binding
Mitotic Cell Cycle Phase Transition
Cyclin A2-CDK2 Complex
Cell Cycle Phase Transition
Homologous Chromosome Segregation
Deactivation Of Mitotic Spindle Assembly Checkpoint
Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling
Positive Regulation Of Ubiquitin Protein Ligase Activity
Nucleus
Free Ubiquitin Chain Polymerization
Selenocysteine Incorporation
Positive Regulation Of Mitotic Sister Chromatid Segregation
Anaphase-promoting Complex Binding
Mitotic Nuclear Membrane Reassembly
Protein K29-linked Ubiquitination
Transferase Complex
Positive Regulation Of Ubiquitin-protein Transferase Activity
Meiotic Chromosome Segregation
Exit From Mitosis
Regulation Of Exit From Mitosis
Protein K27-linked Ubiquitination
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Ubiquitin-like Protein Transferase Activity
Transcription Factor Binding
SUMO Transferase Activity
Positive Regulation Of Mitotic Sister Chromatid Separation
Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Anaphase-promoting Complex-dependent Catabolic Process
Anaphase-promoting Complex
Synaptonemal Complex
Nuclear Membrane Reassembly
Molecular Function Activator Activity
Protein K6-linked Ubiquitination
Regulation Of Ubiquitin-protein Transferase Activity
Male Meiosis I
Presynaptic Cytosol
Postsynaptic Cytosol
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Positive Regulation Of Chromosome Segregation
Male Gamete Generation
Post-translational Protein Modification
Proteolysis
Protein Modification Process
Protein Ubiquitination
Modification-dependent Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Proteolysis Involved In Protein Catabolic Process
Anaphase-promoting Complex-dependent Catabolic Process
Protein Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Anaphase-promoting Complex
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K11-linked Ubiquitination
Macromolecule Catabolic Process
Protein Deubiquitination
Proteasomal Protein Catabolic Process
Protein Modification By Small Protein Removal
Protein Catabolic Process
Protein Branched Polyubiquitination
Protein Polyubiquitination
Macromolecule Metabolic Process
Catabolic Process
Regulation Of Meiotic Cell Cycle
Regulation Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Cysteine-type Deubiquitinase Activity
Protein K48-linked Ubiquitination
Regulation Of Sister Chromatid Segregation
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Cytosol
Positive Regulation Of Mitotic Sister Chromatid Separation
Cysteine-type Peptidase Activity
Regulation Of Chromosome Segregation
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle
Regulation Of Chromosome Organization
Positive Regulation Of Chromosome Separation
Positive Regulation Of Cell Cycle Phase Transition
Regulation Of Reproductive Process
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Cell Cycle
Regulation Of Mitotic Metaphase/anaphase Transition
Metaphase/anaphase Transition Of Cell Cycle
Ubiquitin Binding
Ubiquitin-protein Transferase Activity
Regulation Of Mitotic Sister Chromatid Separation
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Chromosome Separation
Peptidase Activity
Regulation Of Mitotic Cell Cycle Phase Transition
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?