TMEM88 and GYPC

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TMEM88	GYPC
Name		transmembrane protein 88	glycophorin C (Gerbich blood group)
Structure		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane	Plasma Membrane Membrane Cortical Cytoskeleton
	Molecular Function	Protein Binding PDZ Domain Binding	Protein Binding
	Biological Process	Wnt Signaling Pathway Protein Stabilization Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway	None
Pathways		None	Cell surface interactions at the vascular wall
GWAS		Brain morphology (MOSTest) ( 32665545 )	Atrial fibrillation ( 29892015 30061737 ) Diastolic blood pressure ( 30224653 ) Hemoglobin levels ( 32327693 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Initial pursuit acceleration ( 29064472 ) Intelligence ( 22449649 ) Metabolite levels ( 23823483 ) Pelvic organ prolapse (moderate/severe) ( 26545240 ) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Systolic blood pressure ( 31217584 ) Tea consumption ( 31046077 )
Interacting Genes		9 interacting genes: GYPC MFF NKG7 TIMM23 TMEM11 TMEM218 TMEM50B VRK2 ZDHHC22	13 interacting genes: ABHD16A AQP6 EPB41 GPR42 MPP1 PDIA3 PLPPR2 RHBDD1 SHISAL1 SLC10A6 TMEM14B TMEM88 TSPAN15
Entrez ID		92162	2995
HPRD ID		17438	00193
Ensembl ID		ENSG00000167874	ENSG00000136732
Uniprot IDs		I3L2J3 Q6PEY1	P04921
PDB IDs		Not available	2EJY
GO Terms Enriched among Interactors		Protein Targeting Protein Targeting To Mitochondrion Membrane Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Organelle Envelope Establishment Of Protein Localization To Mitochondrion	PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Membrane Cortical Cytoskeleton Tapasin-ERp57 Complex Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Membrane Protein Proteolysis Involved In Retrograde Protein Transport, ER To Cytosol Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport