ZMYM6 and NRF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZMYM6	NRF1
Description		zinc finger MYM-type containing 6	nuclear respiratory factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Cytoskeleton Organization Regulation Of Cell Morphogenesis	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways			PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Mitochondrial unfolded protein response (UPRmt)
Drugs
Diseases
GWAS		Serum uric acid levels in response to allopurinol in gout ( 25676789)	Bipolar disorder ( 31043756) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Response to antidepressants and depression ( 27622933)
Interacting Genes		10 interacting genes: BANP BEND2 CDK9 CTCF LMNA NFYC NRF1 POU2F1 ZBTB24 ZNF76	48 interacting genes: AGR2 BBS2 BICRAL BRWD1 C10orf55 C3orf36 CKMT2 COL10A1 CSNK2A1 CSNK2B DYNLL1 ESM1 FHL2 HHIPL1 HIVEP1 KHDC4 KLF15 KPNA5 KRT83 L3MBTL2 L3MBTL3 LHX3 LHX4 LHX6 LMO4 MAFF MVP NDUFAB1 PANX2 PARP1 PLXDC1 POGZ PPARGC1A PPRC1 SIAH2 SLC67A1-AS SP2 SP4 SPMIP10 SPSB2 SRARP TESMIN TOLLIP TRAF2 TRIM35 VEZF1 YPEL3 ZMYM6
Entrez ID		9204	4899
HPRD ID		10325	02930
Ensembl ID		ENSG00000163867	ENSG00000106459
Uniprot IDs		O95789	Q16656
PDB IDs			8K3D 8K4L
Enriched GO Terms of Interacting Partners?		DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Localization Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Metabolic Process Cardiac Muscle Cell Development Cardiac Cell Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Loop Anchoring Activity Regulation Of Gene Expression Striated Muscle Cell Development Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Organization Regulation Of Primary Metabolic Process P-TEFb Complex DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Muscle Cell Development Positive Regulation Of Protein Localization To Chromatin Sequence-specific DNA Binding Nucleoplasm Regulation Of Macromolecule Metabolic Process Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Insulator Sequence Binding Transcription Pausing By RNA Polymerase II Lamin Filament Heterochromatin Formation Nuclear Pore Localization CCAAT-binding Factor Complex RNA Polymerase II Transcription Regulator Complex Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Protein Localization To Chromatin Transcription Elongation-coupled Chromatin Remodeling Negative Regulation Of Gene Expression, Epigenetic	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Medial Motor Column Neuron Differentiation Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Chromatin Zinc Ion Binding Regulation Of Primary Metabolic Process Motor Neuron Axon Guidance Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Metabolic Process Metal Ion Binding Regulation Of Macromolecule Biosynthetic Process Spinal Cord Motor Neuron Cell Fate Specification Cell Differentiation In Spinal Cord RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Spinal Cord Association Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Apoptotic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Programmed Cell Death Cell Death Negative Regulation Of Macromolecule Metabolic Process Nucleoplasm
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