NFKBIE and PEX6

		NFKBIE	PEX6
Description		NFKB inhibitor epsilon	peroxisomal biogenesis factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Cytoplasm Cytosol	Photoreceptor Outer Segment Cytoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Cell Projection Photoreceptor Cell Cilium
	Molecular Function	Protein Binding Protein Sequestering Activity	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Protein-containing Complex Binding Ubiquitin-modified Protein Reader Activity Protein Transporter Activity
	Biological Process		Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Protein Stabilization
Pathways		Activation of NF-kappaB in B cells	Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases		Hodgkin lymphoma	Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Rheumatoid arthritis ( 22446963 23028356 24390342 30423114 32723749)	Alzheimer's disease in APOE e4+ carriers ( 25778476) Hematocrit ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		15 interacting genes: ANKHD1 C1QBP CUL1 HDAC4 HDAC5 IL1A JUP KBTBD7 NCOR2 NFKB1 NFKB2 PPP6C REL RELA SKP1	8 interacting genes: ATF7IP CERS2 PEX1 PEX26 PEX5 RPL27A RPS14 SMAD3
Entrez ID		4794	5190
HPRD ID		05181	03293
Ensembl ID		ENSG00000146232	ENSG00000124587
Uniprot IDs		O00221 Q7LC14 Q96F31	Q13608
PDB IDs
Enriched GO Terms of Interacting Partners?		Non-canonical NF-kappaB Signal Transduction Defense Response Response To External Biotic Stimulus NF-kappaB P50/p65 Complex Canonical NF-kappaB Signal Transduction Immune System Process I-kappaB/NF-kappaB Complex Immune Response Innate Immune Response NF-kappaB Complex Histone Deacetylase Binding Defense Response To Symbiont Defense Response To Other Organism Response To Lipopolysaccharide Cytosol Inflammatory Response Response To Molecule Of Bacterial Origin Cellular Response To Nicotine Ubiquitin Ligase Complex Scaffold Activity Cellular Response To Lipopolysaccharide Regulation Of Interleukin-12 Production Histone Deacetylase Activity, Hydrolytic Mechanism Positive Regulation Of Transcription By RNA Polymerase II Response To Stress Cellular Response To Molecule Of Bacterial Origin Protein Lysine Deacetylase Activity Actinin Binding Nucleoplasm Tissue Remodeling Positive Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Angiotensin Regulation Of MiRNA Metabolic Process Cellular Response To Interleukin-6 Negative Regulation Of Interleukin-12 Production Negative Regulation Of Myotube Differentiation Response To Other Organism Histone Deacetylase Activity Transcription Cis-regulatory Region Binding Response To Interleukin-6 Regulation Of Transcription By RNA Polymerase II Response To Lipid Protein K48-linked Ubiquitination Nucleus Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Protein Sumoylation DNA-binding Transcription Activator Activity Response To Angiotensin Response To Cytokine Response To Muscle Stretch	Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Establishment Of Protein Localization To Peroxisome Peroxisomal Membrane Transport Peroxisome Organization Receptor Recycling Intracellular Protein Transmembrane Transport Receptor Metabolic Process Protein Import Into Peroxisome Membrane Peroxisomal Membrane Protein Transmembrane Transport Protein Targeting To Peroxisome Peroxisome Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Negative Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Cytosol Establishment Of Protein Localization To Organelle Positive Regulation Of Transforming Growth Factor Beta3 Production Microtubule-based Peroxisome Localization Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Cytosolic Ribosome Sterol Response Element Binding Paraxial Mesoderm Morphogenesis Peroxisome Targeting Sequence Binding Negative Regulation Of Schwann Cell Migration Cytoplasmic Translation Regulation Of Lung Blood Pressure Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Matrix, Docking Intracellular Protein Transport Mesoderm Morphogenesis Immune System Development Structural Constituent Of Ribosome Protein To Membrane Docking Pericardium Development Protein Import Into Peroxisome Matrix, Substrate Release Sphingosine N-acyltransferase Activity Transdifferentiation SMAD Protein Complex Trophoblast Cell Migration Regulation Of Response To Wounding Protein Localization To Organelle Negative Regulation Of Glial Cell Migration DEAD/H-box RNA Helicase Binding Heteromeric SMAD Protein Complex Regulation Of Transforming Growth Factor Beta2 Production Ribosome
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