SLC16A7 and COMT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC16A7	COMT
Description		solute carrier family 16 member 7	catechol-O-methyltransferase
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Parallel Fiber To Purkinje Cell Synapse Postsynaptic Density Membrane Glutamatergic Synapse	Cytoplasm Cytosol Plasma Membrane Membrane Axon Dendrite Vesicle Synapse Extracellular Exosome
	Molecular Function	Pyruvate Secondary Active Transmembrane Transporter Activity Protein Binding Monocarboxylic Acid Transmembrane Transporter Activity Lactate Transmembrane Transporter Activity Symporter Activity Secondary Active Monocarboxylate Transmembrane Transporter Activity Transmembrane Transporter Activity Identical Protein Binding Pyruvate Transmembrane Transporter Activity	Magnesium Ion Binding Protein Binding Methyltransferase Activity O-methyltransferase Activity Catechol O-methyltransferase Activity Transferase Activity Metal Ion Binding
	Biological Process	Monocarboxylic Acid Transport Lactate Transmembrane Transport Plasma Membrane Lactate Transport Transmembrane Transport Transport Across Blood-brain Barrier Pyruvate Transmembrane Transport	Behavioral Fear Response Response To Hypoxia Kidney Development Synaptic Transmission, Dopaminergic Startle Response Response To Amphetamine Renin Secretion Into Blood Stream Glycogen Metabolic Process Catecholamine Metabolic Process Lipid Metabolic Process Prostaglandin Metabolic Process Response To Stress Response To Oxidative Stress Learning Or Memory Learning Memory Regulation Of Blood Pressure Visual Learning Response To Temperature Stimulus Response To Xenobiotic Stimulus Response To Wounding Response To Toxic Substance Gene Expression Dopamine Secretion Cellular Response To Phosphate Starvation Cerebellar Cortex Morphogenesis Response To Food Methylation Developmental Process Glomerulus Development Cholesterol Efflux Multicellular Organismal Response To Stress Response To Cytokine Multicellular Organism Growth Exploration Behavior Renal Sodium Excretion Norepinephrine Metabolic Process Dopamine Metabolic Process Dopamine Catabolic Process Catecholamine Catabolic Process Fear Response Habituation Norepinephrine Secretion Cognition Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Response To Corticosterone Artery Development Cellular Response To Cocaine Mastication Renal Albumin Absorption Renal Filtration Response To Salt Response To Dopamine Response To Angiotensin
Pathways		Proton-coupled monocarboxylate transport	Methylation Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase Potential therapeutics for SARS
Drugs		Pyruvic acid	Ademetionine Tolcapone Entacapone 3,5-Dinitrocatechol 2-Methoxyestradiol BIA N-[(E)-3-[(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]prop-2-enyl]-2,3-dihydroxy-5-nitrobenzamide Nialamide (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE 7,8-dihydroxy-4-phenyl-2H-chromen-2-one Opicapone
Diseases
GWAS		Adventurousness ( 30643258) Calcium levels ( 25972035) General risk tolerance (MTAG) ( 30643258) Hematocrit ( 29403010) Kawasaki disease ( 33692975) Logical memory (delayed recall) in normal cognition ( 29274321) Logical memory (immediate recall) in normal cognition ( 29274321) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Takayasu arteritis ( 25604533)	Serum metabolite levels ( 23093944) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995)
Interacting Genes		15 interacting genes: ACSL5 CDIPT COMT CPEB1 FXYD6 GPR25 HMOX1 IFITM3 LEMD1 SFXN1 SMAGP SNTA1 TIMM23 VAPA VTI1B	68 interacting genes: ACE AQP7 AVPR2 BEST2 CCL4L2 CDC27 CDC42 CNR2 CREB3L1 EMD FAM209A FFAR3 FXR2 GET1 GJB1 GJB3 GJB4 GJB5 GLP1R GPR152 GPR161 GPR42 HIBADH HSD3B7 KCNK5 KRT31 KRT40 KRTAP5-9 LITAF MTNR1A MYADML2 NIPAL4 OTOP3 PGAP2 PLPP6 REEP4 RGS2 RHBDD2 RHBDL1 S1PR3 SELENOK SLC10A6 SLC16A7 SLC2A5 SLC35A4 SLC35F1 SLC39A1 SLC39A2 SLC48A1 SLC71A2 SLC7A8 SMIM1 THSD7A TLCD4 TMEM100 TMEM120B TMEM14B TMEM14C TMEM187 TMEM205 TMEM222 TMEM50A TRHR TRIP13 VAMP3 VAMP5 VKORC1 XRN2
Entrez ID		9194	1312
HPRD ID		06791	00284
Ensembl ID		ENSG00000118596	ENSG00000093010
Uniprot IDs		O60669	A0A140VJG8 P21964
PDB IDs		7BP3	3A7E 3BWM 3BWY 4PYI 4PYJ 4PYK 4XUC 4XUD 4XUE 5LSA 6I3C 6I3D
Enriched GO Terms of Interacting Partners?		Membrane	Membrane Transmembrane Transport Plasma Membrane G Protein-coupled Receptor Activity Connexin Complex Gap Junction Channel Activity G Protein-coupled Receptor Signaling Pathway Gap Junction Transmembrane Transporter Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Nuclear Inner Membrane Regulation Of Blood Pressure Respiratory Burst After Phagocytosis Protein Binding Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Blood Pressure Heme Metabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell Differentiation Regulation Of Gap Junction Assembly Respiratory Burst Involved In Defense Response
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