DDX21 and KPNA3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		DDX21	KPNA3
Gene Name		DEAD (Asp-Glu-Ala-Asp) box helicase 21	karyopherin alpha 3 (importin alpha 4)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Membrane	Nuclear Pore Nucleoplasm Cytosol
	Molecular Function	Double-stranded RNA Binding ATP-dependent RNA Helicase Activity ATP Binding Poly(A) RNA Binding	Protein Binding Protein C-terminus Binding Nuclear Localization Sequence Binding Protein Transporter Activity
	Biological Process	Osteoblast Differentiation Metabolic Process Response To Virus Response To Exogenous DsRNA	Protein Complex Assembly NLS-bearing Protein Import Into Nucleus Cytokine-mediated Signaling Pathway Viral Entry Into Host Cell Viral Penetration Into Host Nucleus
Pathways			ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes
Drugs
Diseases
GWAS		Depression (quantitative trait) ( 20800221)	Menopause (age at onset) ( 22267201) Obesity-related traits ( 23251661)
Protein-Protein Interactions		11 interactors: CALM1 CSNK2A1 ERG H2AFX IL7R JUN KPNA3 PIAS1 SRPK2 TERF1 TERF2	28 interactors: APOL6 CDKN1B COIL DDX21 EPHA2 ERCC3 FAM50B FTL GATA6 GTF2H1 HNRNPC KPNB1 MAT2B MTA1 MVP MYOD1 NFE2L2 NFKB1 NUP50 RCC1 RPRD1A SLC5A11 TEX37 TGM2 TSSC4 ZBTB24 ZCCHC10 ZNF131
Entrez ID		9188	3839
HPRD ID		05895	03536
Ensembl ID		ENSG00000165732	ENSG00000102753
Uniprot IDs		Q9NR30	O00505 Q8IYQ9
PDB IDs		2M3D
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Regulation Of Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Replicative Cell Aging Negative Regulation Of Chromosome Organization Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Response To Stimulus Positive Regulation Of Metabolic Process Cellular Response To Stimulus Regulation Of DNA Replication Regulation Of Telomere Maintenance Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Metabolic Process RNA-dependent DNA Replication Regulation Of Cell Cycle Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Autophosphorylation Regulation Of Proteasomal Protein Catabolic Process Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Cell Cycle Checkpoint Negative Regulation Of Cellular Metabolic Process Mitotic Spindle Checkpoint Immune Response Negative Regulation Of Chromosome Segregation Nucleobase-containing Compound Metabolic Process Regulation Of Cell Division Response To Cytokine Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Negative Regulation Of DNA Replication Negative Regulation Of Ion Transmembrane Transport Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Transmembrane Transport Cellular Nitrogen Compound Metabolic Process Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Aging Negative Regulation Of Proteasomal Protein Catabolic Process	Viral Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Response To Organic Substance Nitrogen Compound Metabolic Process Gene Expression Nucleotide-excision Repair, DNA Damage Removal Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Termination Of RNA Polymerase I Transcription Programmed Cell Death Transcription Elongation From RNA Polymerase I Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Catabolic Process Osteoblast Differentiation Transcription Initiation From RNA Polymerase I Promoter Cell Death Death 7-methylguanosine MRNA Capping Response To Abiotic Stimulus Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping Positive Regulation Of Metabolic Process Regulation Of Gene Expression Transcription-coupled Nucleotide-excision Repair Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Transcription Positive Regulation Of Wound Healing Regulation Of Nucleic Acid-templated Transcription Cellular Response To DNA Damage Stimulus Regulation Of RNA Biosynthetic Process Response To Lipid Response To Estrogen Regulation Of Gene Expression, Epigenetic Negative Regulation Of Interleukin-12 Biosynthetic Process Nucleotide-excision Repair, DNA Duplex Unwinding Notochord Cell Development Regulation Of Cell Cycle Process Cellular Macromolecule Catabolic Process Macromolecule Biosynthetic Process
Tagcloud ?		agar ap array bioluminescence correlates helicase herein immunofluorescence indirect jun localization luciferase lymphomas markedly mechanistically nucleolar processing promote qrt ribosome rrna ser73 soft subcellular subset tumorigenesis tumorigenicity undergo xenograft	alpha4 ataxias capicua desensitize erk ets etv etv1 etv4 etv5 give highlight hmg importin interconnections mechanistic modulating motivating multisite nls p90 pea3 phosphorylations polyoma relieved represses rsk s6 spinocerebellar
Tagcloud (Difference) ?		agar ap array bioluminescence correlates helicase herein immunofluorescence indirect jun localization luciferase lymphomas markedly mechanistically nucleolar processing promote qrt ribosome rrna ser73 soft subcellular subset tumorigenesis tumorigenicity undergo xenograft	alpha4 ataxias capicua desensitize erk ets etv etv1 etv4 etv5 give highlight hmg importin interconnections mechanistic modulating motivating multisite nls p90 pea3 phosphorylations polyoma relieved represses rsk s6 spinocerebellar
Tagcloud (Intersection) ?