EBAG9 and ORMDL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EBAG9	ORMDL1
Description		estrogen receptor binding site associated antigen 9	ORMDL sphingolipid biosynthesis regulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane Secretory Granule	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Serine Palmitoyltransferase Complex
	Molecular Function	Protein Binding Peptidase Activator Activity Involved In Apoptotic Process	Protein Binding
	Biological Process	Regulation Of Cell Growth T Cell Mediated Cytotoxicity Apoptotic Process Adaptive Immune Memory Response Involving T Cells And B Cells	Sphingolipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Biosynthetic Process Sphingolipid Biosynthetic Process Myelination Motor Behavior Regulation Of Sphingolipid Biosynthetic Process Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Regulation Of Ceramide Biosynthetic Process
Pathways		Estrogen-dependent gene expression	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Nicotine dependence and major depression (severity of comorbidity) ( 30287806)	Bilirubin levels ( 20639394) Ferritin levels ( 25162662)
Interacting Genes		30 interacting genes: ACSL5 APOL2 BNIP3 C14orf180 CFHR5 CIAO2A CLEC4G CLN6 GOLPH3 GOLPH3L MGLL NEDD4 OR10AG1 ORMDL1 PEX16 PRAF2 REEP6 SLC30A2 SLC35A1 SLC35A4 SLC35B4 SNAPIN STX1A STX2 STX3 TMEM107 TPRG1 TRAF3IP3 VAPA VAPB	42 interacting genes: APP AQP6 ARL13B ASGR2 BIK CD79A COQ9 CPLX4 CREB3 CREB3L1 EBAG9 EBP EHHADH ERGIC3 FAM209A GPR152 HSD17B11 KCNK4 LMNA LNX1 MTIF3 PCNX2 PGRMC2 REEP4 SAR1A SCN3B SLC10A1 SLC10A6 SLC18A1 SLC30A8 SLC35H1 SLC71A2 STOM TIMMDC1 TLCD4 TMEM143 TMEM14B TMEM35A TMEM52B VMA21 ZDHHC15 ZFYVE27
Entrez ID		9166	94101
HPRD ID		05775	15092
Ensembl ID		ENSG00000147654	ENSG00000128699
Uniprot IDs		O00559	Q9P0S3
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Membrane Docking Vesicle Organization Organelle Localization By Membrane Tethering Vesicle Budding From Membrane Pyrimidine Nucleotide-sugar Transmembrane Transport Endoplasmic Reticulum Membrane Nucleotide-sugar Transmembrane Transport Membrane Organization SNARE Binding Membrane Fusion FFAT Motif Binding Protein Targeting To Golgi Apparatus Golgi Membrane Golgi Vesicle Budding Cargo Adaptor Activity Cellular Localization Vesicle Fusion COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Organelle Membrane Fusion SNAP Receptor Activity Endoplasmic Reticulum Localization Protein Transport SNARE Complex Organelle Fusion Organophosphate Ester Transport Golgi Cisterna Organelle Localization Intracellular Protein Localization Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Intracellular Transport Host-mediated Activation Of Viral Genome Replication Organelle Organization Vesicle Fusion To Plasma Membrane Endoplasmic Reticulum Organization Host-mediated Perturbation Of Viral Genome Replication Sphingomyelin Biosynthetic Process Vesicle Docking Establishment Of Localization In Cell Host-mediated Suppression Of Viral Genome Replication Establishment Of Protein Localization Intracellular Chemical Homeostasis Intracellular Protein Transport Synaptic Vesicle Membrane Organization Carbohydrate Derivative Transport Zymogen Granule Membrane Exocytosis	Membrane Endoplasmic Reticulum Protein Binding Bile Acid:sodium Symporter Activity Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Membrane
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