SART3 and C6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SART3	C6
Description		spliceosome associated factor 3, U4/U6 recycling protein	complement C6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm U6atac SnRNP Cytoplasm Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex ASAP Complex U4/U6 SnRNP U4atac/U6atac SnRNP	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Transmembrane Transporter Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding U6 SnRNA Binding U4 SnRNA Binding U6atac SnRNA Binding Protein-macromolecule Adaptor Activity Histone Binding Ubiquitin-specific Protease Binding	Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Cell Morphogenesis Nucleosome Assembly RNA Processing MRNA Processing RNA Splicing Regulation Of Gene Expression Homeostasis Of Number Of Cells Regulation Of RNA Metabolic Process Hematopoietic Stem Cell Proliferation Transcription Elongation-coupled Chromatin Remodeling	In Utero Embryonic Development Immune System Process Immune Response Complement Activation Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Complement Activation, GZMK Pathway
Pathways			Terminal pathway of complement Regulation of Complement cascade
Drugs
Diseases		Disseminated superficial actinic porokeratosis (DSAP)	Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Acne (severe) ( 24927181)	Refractive error ( 32231278) Response to fenofibrate (adiponectin levels) ( 23149075)
Interacting Genes		29 interacting genes: AR C6 COIL CTBP1 H2AC20 H2BC21 MEGF10 MIR1-1 MIR128-2 MIR143 MIR18A MIR18B MIR19B2 MIR200B MIR200C MIR221 MIR34A MIR34B MIR7-1 MIR7-3 MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 PRPF3 RNF10 RNPS1 ZNF620 ZNF71	4 interacting genes: C5 F2 OGA SART3
Entrez ID		9733	729
HPRD ID		11532	01956
Ensembl ID		ENSG00000075856	ENSG00000039537
Uniprot IDs		A0A499FI31 Q15020	P13671
PDB IDs		2DO4 5CTQ 5CTR 5CTT 5JJW 5JJX 5JPZ 7XX8 7XX9	3T5O 4A5W 4E0S 6H03 6H04 7NYC 7NYD 7Q6C 8B0F 8B0G 8B0H
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MRNA Destabilization Negative Regulation Of Metabolic Process RNA Destabilization Positive Regulation Of MRNA Catabolic Process MRNA 3'-UTR Binding Positive Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of Sprouting Angiogenesis Regulation Of RNA Stability Regulation Of MRNA Metabolic Process Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Macromolecule Metabolic Process Regulation Of Muscle Cell Differentiation Regulation Of Angiogenesis Regulation Of Smooth Muscle Cell Differentiation Regulation Of Vasculature Development Regulation Of Metabolic Process Negative Regulation Of Transmembrane Transport Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-33 Production Positive Regulation Of Tissue Remodeling Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Signal Transduction Extracellular Vesicle Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Negative Regulation Of Response To Drug Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Developmental Process Negative Regulation Of Cytokine Production Regulation Of Endothelial Cell Migration	Receptor Ligand Activity Killing Of Cells Of Another Organism U4atac/U6atac SnRNP U6atac SnRNA Binding U6atac SnRNP [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase Activity Cell Killing U4/U6 SnRNP Hexosaminidase Activity Thrombospondin Receptor Activity ASAP Complex Catalytic Activity, Acting On A Protein Humoral Immune Response Other Organism Cell Membrane Negative Regulation Of Macrophage Chemotaxis Membrane Attack Complex Neutrophil-mediated Killing Of Gram-negative Bacterium Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Transcription Elongation-coupled Chromatin Remodeling U4 SnRNA Binding Hyalurononglucosaminidase Activity Complement Activation, Lectin Pathway Transmembrane Transporter Complex Signaling Receptor Binding Negative Regulation Of Macrophage Migration Complement Activation, GZMK Pathway Immune Effector Process Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Astrocyte Differentiation Neutrophil-mediated Killing Of Bacterium Cytolysis By Host Of Symbiont Cells Negative Regulation Of Fibrinolysis U6 SnRNA Binding Complement Activation, Alternative Pathway N-acetylglucosamine Metabolic Process Regulation Of Fibrinolysis Negative Regulation Of Platelet Activation Spliceosomal Tri-snRNP Complex Assembly Fibrinolysis Ubiquitin-specific Protease Binding Protein Deglycosylation Negative Regulation Of Leukocyte Chemotaxis Neutrophil Mediated Immunity Positive Regulation Of Collagen Biosynthetic Process Inflammatory Response Negative Regulation Of Glial Cell Differentiation Hematopoietic Stem Cell Proliferation Positive Regulation Of Blood Coagulation Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Macrophage Chemotaxis
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