SART3 and MIR34A

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		SART3	MIR34A
Description		spliceosome associated factor 3, U4/U6 recycling protein	microRNA 34a
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm U6atac SnRNP Cytoplasm Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex ASAP Complex U4/U6 SnRNP U4atac/U6atac SnRNP	Extracellular Exosome Extracellular Vesicle
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding U6 SnRNA Binding U4 SnRNA Binding U6atac SnRNA Binding Protein-macromolecule Adaptor Activity Histone Binding Ubiquitin-specific Protease Binding	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Cell Morphogenesis Nucleosome Assembly RNA Processing MRNA Processing RNA Splicing Regulation Of Gene Expression Homeostasis Of Number Of Cells Regulation Of RNA Metabolic Process Hematopoietic Stem Cell Proliferation Transcription Elongation-coupled Chromatin Remodeling	DNA Damage Response Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Lipid Storage Negative Regulation Of Angiogenesis Negative Regulation Of Chemokine Production Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Transmembrane Transport MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Cholesterol Homeostasis Response To Axon Injury Negative Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Differentiation Regulation Of Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Vascular Wound Healing Triglyceride Homeostasis Cellular Response To Hypoxia Negative Regulation Of IP-10 Production Negative Regulation Of Smooth Muscle Cell Chemotaxis Negative Regulation Of Calcium Ion Import Programmed Cell Death In Response To Reactive Oxygen Species Positive Regulation Of Blood Vessel Endothelial Cell Differentiation Negative Regulation Of Amyloid-beta Clearance Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Connective Tissue Replacement Negative Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Cellular Senescence
Pathways
Drugs
Diseases		Disseminated superficial actinic porokeratosis (DSAP)
GWAS		Acne (severe) ( 24927181)	Height ( 31562340) Lean body mass ( 28552196)
Interacting Genes		29 interacting genes: AR C6 COIL CTBP1 H2AC20 H2BC21 MEGF10 MIR1-1 MIR128-2 MIR143 MIR18A MIR18B MIR19B2 MIR200B MIR200C MIR221 MIR34A MIR34B MIR7-1 MIR7-3 MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 PRPF3 RNF10 RNPS1 ZNF620 ZNF71	102 interacting genes: ADARB1 AIMP1 AIMP2 APOBEC3B AQR ATXN2L C1QBP CDC5L CELF1 CPSF1 CPSF6 DARS1 DDX1 DDX21 DDX3X DDX3Y DHX36 DHX37 EDC4 EIF2AK2 EPRS1 ESRP1 FAM98A FAM98B FIP1L1 FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PGAM5 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PUM1 PURA QARS1 RARS1 RBFOX2 RBM12B RBM14 RBM4 RTCB SART3 SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SYMPK SYNCRIP TAF15 TIAL1 TRA2A TRA2B TRIM25 TRMT1L U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZNF346
Entrez ID		9733	407040
HPRD ID		11532
Ensembl ID		ENSG00000075856	ENSG00000284357
Uniprot IDs		A0A499FI31 Q15020
PDB IDs		2DO4 5CTQ 5CTR 5CTT 5JJW 5JJX 5JPZ 7XX8 7XX9
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MRNA Destabilization Negative Regulation Of Metabolic Process RNA Destabilization Positive Regulation Of MRNA Catabolic Process MRNA 3'-UTR Binding Positive Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of Sprouting Angiogenesis Regulation Of RNA Stability Regulation Of MRNA Metabolic Process Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Macromolecule Metabolic Process Regulation Of Muscle Cell Differentiation Regulation Of Angiogenesis Regulation Of Smooth Muscle Cell Differentiation Regulation Of Vasculature Development Regulation Of Metabolic Process Negative Regulation Of Transmembrane Transport Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-33 Production Positive Regulation Of Tissue Remodeling Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Signal Transduction Extracellular Vesicle Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Negative Regulation Of Response To Drug Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Developmental Process Negative Regulation Of Cytokine Production Regulation Of Endothelial Cell Migration	RNA Binding Nucleic Acid Binding RNA Metabolic Process RNA Processing Nucleic Acid Metabolic Process MRNA Metabolic Process RNA Splicing MRNA Processing Nucleobase-containing Compound Metabolic Process MRNA Binding Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleus Regulation Of RNA Splicing Nucleoplasm Regulation Of MRNA Metabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex Spliceosomal Complex Cytoplasmic Stress Granule Catalytic Step 2 Spliceosome Ribonucleoprotein Complex Post-transcriptional Regulation Of Gene Expression MRNA 3'-UTR Binding Regulation Of MRNA Processing Regulation Of Translation Regulation Of MRNA Splicing, Via Spliceosome MiRNA Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Regulation Of Macromolecule Metabolic Process TRNA Aminoacylation Negative Regulation Of Translation TRNA Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of RNA Stability Negative Regulation Of MRNA Catabolic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process RNA Stabilization Regulation Of MRNA Stability Ligase Activity U2 SnRNP MRNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly Positive Regulation Of Cytoplasmic Translation
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