SART3 and MIR221

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		SART3	MIR221
Description		spliceosome associated factor 3, U4/U6 recycling protein	microRNA 221
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm U6atac SnRNP Cytoplasm Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex ASAP Complex U4/U6 SnRNP U4atac/U6atac SnRNP	Extracellular Space RISC Complex Extracellular Vesicle
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding U6 SnRNA Binding U4 SnRNA Binding U6atac SnRNA Binding Protein-macromolecule Adaptor Activity Histone Binding Ubiquitin-specific Protease Binding	MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Cell Morphogenesis Nucleosome Assembly RNA Processing MRNA Processing RNA Splicing Regulation Of Gene Expression Homeostasis Of Number Of Cells Regulation Of RNA Metabolic Process Hematopoietic Stem Cell Proliferation Transcription Elongation-coupled Chromatin Remodeling	Inflammatory Response Negative Regulation Of Cell Population Proliferation Response To Glucose Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Interleukin-21 Production Negative Regulation Of Heterotypic Cell-cell Adhesion MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Axon Regeneration Negative Regulation Of Inflammatory Response Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Necroptotic Process Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Schwann Cell Migration Negative Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Schwann Cell Proliferation Involved In Axon Regeneration Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Negative Regulation Of Double-strand Break Repair
Pathways
Drugs
Diseases		Disseminated superficial actinic porokeratosis (DSAP)
GWAS		Acne (severe) ( 24927181)
Interacting Genes		29 interacting genes: AR C6 COIL CTBP1 H2AC20 H2BC21 MEGF10 MIR1-1 MIR128-2 MIR143 MIR18A MIR18B MIR19B2 MIR200B MIR200C MIR221 MIR34A MIR34B MIR7-1 MIR7-3 MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 PRPF3 RNF10 RNPS1 ZNF620 ZNF71	87 interacting genes: ADARB1 AIMP2 APOBEC3B AQR C1QBP CELF1 CPSF1 DARS1 DDX1 DDX21 DDX3X DHX36 EIF2AK2 EPRS1 ERAL1 FAM98A FIP1L1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 MYEF2 NOL6 NONO NUDT21 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PUM2 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCB SART3 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TRA2A TRA2B TRIM25 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZNF346
Entrez ID		9733	407006
HPRD ID		11532
Ensembl ID		ENSG00000075856	ENSG00000207870
Uniprot IDs		A0A499FI31 Q15020
PDB IDs		2DO4 5CTQ 5CTR 5CTT 5JJW 5JJX 5JPZ 7XX8 7XX9
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MRNA Destabilization Negative Regulation Of Metabolic Process RNA Destabilization Positive Regulation Of MRNA Catabolic Process MRNA 3'-UTR Binding Positive Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability Regulation Of Sprouting Angiogenesis Regulation Of RNA Stability Regulation Of MRNA Metabolic Process Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Macromolecule Metabolic Process Regulation Of Muscle Cell Differentiation Regulation Of Angiogenesis Regulation Of Smooth Muscle Cell Differentiation Regulation Of Vasculature Development Regulation Of Metabolic Process Negative Regulation Of Transmembrane Transport Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Interleukin-33 Production Positive Regulation Of Tissue Remodeling Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Signal Transduction Extracellular Vesicle Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane Negative Regulation Of Response To Drug Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Developmental Process Negative Regulation Of Cytokine Production Regulation Of Endothelial Cell Migration	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Metabolic Process Regulation Of RNA Splicing Nucleus Post-transcriptional Regulation Of Gene Expression Spliceosomal Complex Aminoacyl-tRNA Synthetase Multienzyme Complex Nucleoplasm Catalytic Step 2 Spliceosome Regulation Of Translation Ribonucleoprotein Complex Cytoplasmic Stress Granule Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome MiRNA Binding MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of RNA Stability Regulation Of Primary Metabolic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of MRNA Stability TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation MRNA Stabilization U2 SnRNP Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Macromolecule Metabolic Process Ligase Activity
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