PIP4P1 and EPN2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PIP4P1	EPN2
Description		phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1	epsin 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Lysosome Lysosomal Membrane Endosome Plasma Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane	Cytoplasm Endosome Cytosol Plasma Membrane Clathrin Vesicle Coat Clathrin-coated Vesicle Cytoplasmic Vesicle
	Molecular Function	Protein Binding Hydrolase Activity Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity	Protein Binding Phospholipid Binding Lipid Binding Clathrin Binding Cadherin Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Response To Sterol Depletion Cholesterol Metabolic Process Lysosome Localization Phosphatidylinositol Dephosphorylation Proton-transporting V-type ATPase Complex Assembly Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of TORC1 Signaling	Endocytosis Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Sprouting Angiogenesis
Pathways		PI5P Regulates TP53 Acetylation Synthesis of PIPs in the nucleus	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS			Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 30224653) White matter hyperintensities ( 32358547) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		5 interacting genes: EPN2 PLEKHB2 RILPL1 SLC10A6 YAP1	42 interacting genes: APOE ARRDC1 ARRDC2 ARRDC3 ATXN1 CDIP1 CLTC DAZAP2 EIF3E EPS15 FAIM2 FAM168A FANCM ITSN1 LAPTM5 LITAF MID1 MID2 MLANA PIP4P1 PLEKHB2 PMEPA1 PRKAA2 RNF11 RNF8 RPS27A SMAD1 SNCA SPART TFAP2A THOP1 TRIM23 TRIM26 TRIM62 TUBA1B TXLNA UBA52 UBC WBP1 WBP1L WBP2 YWHAG
Entrez ID		90809	22905
HPRD ID		12660	06271
Ensembl ID		ENSG00000165782	ENSG00000072134
Uniprot IDs		Q86T03	O95208
PDB IDs		8OQH
Enriched GO Terms of Interacting Partners?		Regulation Of Notch Signaling Pathway Positive Regulation Of Notch Signaling Pathway Enterocyte Differentiation Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Lateral Mesoderm Development TEAD-YAP Complex Cardiac Muscle Tissue Regeneration Cell Morphogenesis Protein Transport From Ciliary Membrane To Plasma Membrane	Ubiquitin Protein Ligase Binding Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification WW Domain Binding Endosome Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Protein Sequestering Activity Protein Tag Activity Cytoplasmic Side Of Late Endosome Membrane Identical Protein Binding Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Lysosome Ubiquitin Protein Ligase Activity Regulation Of Signal Transduction Protein K6-linked Ubiquitination Protein Binding Intracellular Protein Localization Positive Regulation Of Cell Communication Receptor-mediated Endocytosis Cytoplasm Regulation Of Signaling Protein Polyubiquitination Modification-dependent Protein Catabolic Process Protein Modification Process Negative Regulation Of Signal Transduction Phosphoprotein Binding Clathrin Coat Of Coated Pit Mitochondrial Outer Membrane Positive Regulation Of Protein Ubiquitination Macromolecule Catabolic Process Negative Regulation Of Signaling Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Communication Establishment Of Protein Localization Positive Regulation Of Receptor Catabolic Process Regulation Of Cell Communication Postsynaptic Endocytic Zone Negative Regulation Of Translational Initiation Proteolysis Involved In Protein Catabolic Process Cytoplasmic Translation Lysosomal Membrane Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Signal Transduction Protein Localization To Lysosome Positive Regulation Of Receptor Recycling Cytoplasmic Side Of Lysosomal Membrane Catabolic Process
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