PIP4P1 and PLEKHB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PIP4P1	PLEKHB2
Description		phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1	pleckstrin homology domain containing B2
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GO Annotations	Cellular Component	Nucleoplasm Lysosome Lysosomal Membrane Endosome Plasma Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane	Endosome Membrane Recycling Endosome Membrane
	Molecular Function	Protein Binding Hydrolase Activity Phosphatidylinositol-4,5-bisphosphate 4-phosphatase Activity	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding
	Biological Process	Lipid Metabolic Process Phospholipid Metabolic Process Response To Sterol Depletion Cholesterol Metabolic Process Lysosome Localization Phosphatidylinositol Dephosphorylation Proton-transporting V-type ATPase Complex Assembly Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of TORC1 Signaling	Regulation Of Cell Differentiation
Pathways		PI5P Regulates TP53 Acetylation Synthesis of PIPs in the nucleus
Drugs
Diseases
GWAS
Interacting Genes		5 interacting genes: EPN2 PLEKHB2 RILPL1 SLC10A6 YAP1	51 interacting genes: ATF7IP BHLHE40 C1orf94 CD68 CDA CFTR CLDN19 DAZAP2 DCUN1D1 EMP1 EMP3 EPN1 EPN2 FAM168A FOXD4L3 GGA3 GJB2 GLIS2 HEY1 HEYL HGS HIVEP1 MAP3K1 MED25 MTURN NTAQ1 OTUB2 PIP4P1 PITX1 POGZ PROP1 RHBDD1 RPS27A RUNX1 SFT2D1 SNRPB STAM2 SYNGR1 TAX1BP1 TRARG1 UBA52 UBAC1 UBAP2 UBASH3A UBB UBC UBQLN2 UBXN6 UPF1 YOD1 ZFAND2A
Entrez ID		90809	55041
HPRD ID		12660	15144
Ensembl ID		ENSG00000165782	ENSG00000115762
Uniprot IDs		Q86T03	A0A0A0MSE9 A0A0A0MSI4 B4DJB7 Q96CS7
PDB IDs		8OQH	3AJ4 3VIA
Enriched GO Terms of Interacting Partners?		Regulation Of Notch Signaling Pathway Positive Regulation Of Notch Signaling Pathway Enterocyte Differentiation Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Lateral Mesoderm Development TEAD-YAP Complex Cardiac Muscle Tissue Regeneration Cell Morphogenesis Protein Transport From Ciliary Membrane To Plasma Membrane	Protein Tag Activity Endosome Membrane ESCRT-0 Complex Positive Regulation Of Macromolecule Metabolic Process Cytoplasm DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Macromolecule Catabolic Process Endocytic Vesicle Membrane Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Autophagy Endosome Transport Via Multivesicular Body Sorting Pathway Ubiquitin Binding Clathrin Vesicle Coat ERAD Pathway Early Endosome Membrane Bleb Assembly Multivesicular Body Sorting Pathway Endosome Protein K11-linked Deubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
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