SUPT3H

Name	SPT3 homolog, SAGA and STAGA complex component
Structure
Interactors	5 interactors: DDB1 H3-4 MYC PYGO2 TCF3
GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Transcription Factor TFTC Complex
	Molecular Function	Transcription Coactivator Activity Protein Heterodimerization Activity
	Biological Process	Regulation Of DNA Repair Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription
Pathways	HATs acetylate histones
GWAS	ADAMTS13 activity ( 25934476 ) Appendicular lean mass ( 33097823 ) Attention deficit hyperactivity disorder ( 18839057 ) Chin dimples ( 27182965 ) Estimated glomerular filtration rate ( 31152163 ) facial morphology traits (multivariate analysis) ( 27193062 ) Glaucoma ( 31959993 ) Heel bone mineral density ( 30598549 28869591 ) Height ( 23563607 31562340 28552196 18391951 25429064 19893584 25282103 ) Hip circumference adjusted for BMI ( 34021172 ) Hip minimal joint space width ( 27701424 ) Intraocular pressure ( 31959993 30054594 ) Large artery stroke ( 24262325 ) Lumbar spine bone mineral density ( 22504420 ) Lymphocyte count ( 32888494 ) Male-pattern baldness ( 27182965 ) Monobrow ( 27182965 ) Nose morphology ( 29921221 ) Nose size ( 27182965 ) Obesity-related traits ( 23251661 ) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288 ) Ossification of the posterior longitudinal ligament of the spine ( 25064007 ) Osteoarthritis ( 22763110 ) Osteoarthritis of the hand ( 28855172 ) Osteoarthritis of the hip or knee ( 30664745 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Serum alkaline phosphatase levels ( 33547301 ) Stroke (ischemic) ( 22941190 ) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429 ) Waist circumference adjusted for body mass index ( 34021172 )
Entrez ID	8464
HPRD ID	04254
Ensembl ID	ENSG00000196284
Uniprot IDs	B4E1H0 O75486
PDB IDs	7KTR 7KTS 8H7G
GO Terms Enriched among Interactors ?	Wnt Signaling Pathway Cellular Response To UV E-box Binding Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Acinar Cell Proliferation Euchromatin SCF Ubiquitin Ligase Complex Binding Cellular Response To Light Stimulus Nucleoplasm Response To UV Regulation Of Cell Cycle Process Chromatin Remodeling Cellular Response To Radiation Protein-containing Complex DNA Binding Chromatin Organization Positive Regulation By Virus Of Viral Protein Levels In Host Cell Chromosome, Telomeric Region NK T Cell Proliferation Myc-Max Complex Regulation Of Acinar Cell Proliferation Protein Dimerization Activity Positive Regulation Of B Cell Apoptotic Process DNA-binding Transcription Factor Binding Vitamin D Response Element Binding Spermatogonial Cell Division Histone Acetyltransferase Regulator Activity Base-excision Repair, AP Site Formation Via Deaminated Base Removal WD40-repeat Domain Binding Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Developmental Process Negative Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Monocyte Differentiation B Cell Lineage Commitment DNA Replication-dependent Chromatin Assembly Ubiquitin Ligase Complex Scaffold Activity Regulation Of Cell Cycle RNA Polymerase II Transcription Repressor Complex DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Immunoglobulin V(D)J Recombination Epigenetic Regulation Of Gene Expression NK T Cell Activation Positive Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Kidney Development Cellular Response To Interferon-alpha