SUPT3H and PYGO2

Number of citations: 62 (PubMedID 20937768)
Data Source: BioGRID (pull down)

		SUPT3H	PYGO2
Name		SPT3 homolog, SAGA and STAGA complex component	pygopus family PHD finger 2
Structure
GO Annotations	Cellular Component	SAGA Complex Nucleus Nucleoplasm Transcription Factor TFTC Complex	Nucleus Nucleoplasm Beta-catenin-TCF Complex
	Molecular Function	Transcription Coactivator Activity Protein Heterodimerization Activity	Chromatin Binding Protein Binding Zinc Ion Binding Histone Acetyltransferase Regulator Activity Histone Binding Metal Ion Binding
	Biological Process	Regulation Of DNA Repair Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription	Kidney Development Lens Development In Camera-type Eye Spermatid Development Spermatid Nucleus Differentiation Brain Development Wnt Signaling Pathway Mammary Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Developmental Growth Roof Of Mouth Development Canonical Wnt Signaling Pathway
Pathways		HATs acetylate histones	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
GWAS		ADAMTS13 activity ( 25934476 ) Appendicular lean mass ( 33097823 ) Attention deficit hyperactivity disorder ( 18839057 ) Chin dimples ( 27182965 ) Estimated glomerular filtration rate ( 31152163 ) facial morphology traits (multivariate analysis) ( 27193062 ) Glaucoma ( 31959993 ) Heel bone mineral density ( 30598549 28869591 ) Height ( 23563607 31562340 28552196 18391951 25429064 19893584 25282103 ) Hip circumference adjusted for BMI ( 34021172 ) Hip minimal joint space width ( 27701424 ) Intraocular pressure ( 31959993 30054594 ) Large artery stroke ( 24262325 ) Lumbar spine bone mineral density ( 22504420 ) Lymphocyte count ( 32888494 ) Male-pattern baldness ( 27182965 ) Monobrow ( 27182965 ) Nose morphology ( 29921221 ) Nose size ( 27182965 ) Obesity-related traits ( 23251661 ) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288 ) Ossification of the posterior longitudinal ligament of the spine ( 25064007 ) Osteoarthritis ( 22763110 ) Osteoarthritis of the hand ( 28855172 ) Osteoarthritis of the hip or knee ( 30664745 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Serum alkaline phosphatase levels ( 33547301 ) Stroke (ischemic) ( 22941190 ) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429 ) Waist circumference adjusted for body mass index ( 34021172 )	Bipolar disorder ( 31043756 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Inflammatory bowel disease ( 27569725 ) Prostate cancer ( 23535732 )
Interacting Genes		5 interacting genes: DDB1 H3-4 MYC PYGO2 TCF3	7 interacting genes: AKT1 BCL9 DCAF1 KAT2A NF2 SUPT3H TRRAP
Entrez ID		8464	90780
HPRD ID		04254	06065
Ensembl ID		ENSG00000196284	ENSG00000163348
Uniprot IDs		B4E1H0 O75486	Q5T170 Q9BRQ0
PDB IDs		7KTR 7KTS 8H7G	2XB1 4UP0 4UP5 8HIB
GO Terms Enriched among Interactors		Wnt Signaling Pathway Cellular Response To UV E-box Binding Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Acinar Cell Proliferation Euchromatin SCF Ubiquitin Ligase Complex Binding Cellular Response To Light Stimulus Nucleoplasm Response To UV Regulation Of Cell Cycle Process Chromatin Remodeling Cellular Response To Radiation Protein-containing Complex DNA Binding Chromatin Organization Positive Regulation By Virus Of Viral Protein Levels In Host Cell Chromosome, Telomeric Region NK T Cell Proliferation Myc-Max Complex Regulation Of Acinar Cell Proliferation Protein Dimerization Activity Positive Regulation Of B Cell Apoptotic Process DNA-binding Transcription Factor Binding Vitamin D Response Element Binding Spermatogonial Cell Division Histone Acetyltransferase Regulator Activity Base-excision Repair, AP Site Formation Via Deaminated Base Removal WD40-repeat Domain Binding Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Developmental Process Negative Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Monocyte Differentiation B Cell Lineage Commitment DNA Replication-dependent Chromatin Assembly Ubiquitin Ligase Complex Scaffold Activity Regulation Of Cell Cycle RNA Polymerase II Transcription Repressor Complex DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Immunoglobulin V(D)J Recombination Epigenetic Regulation Of Gene Expression NK T Cell Activation Positive Regulation Of Cell Proliferation Involved In Kidney Development Negative Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Kidney Development Cellular Response To Interferon-alpha	Transcription Factor TFTC Complex SAGA Complex Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Regulation Of RNA Splicing Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Metabolic Process Positive Regulation Of RNA Biosynthetic Process Response To Nerve Growth Factor Regulation Of Organelle Assembly Positive Regulation Of DNA-templated Transcription Cellular Response To Nerve Growth Factor Stimulus Transcription Coactivator Activity Regulation Of DNA Repair Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Gluconeogenesis Hexose Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Striated Muscle Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of TRNA Methylation Regulation Of Cell Cycle Peptidyl-lysine Glutarylation Histone Glutaryltransferase Activity Histone Succinyltransferase Activity Peptide Glutaryltransferase Activity Histone H2AT120 Kinase Activity Cell Competition In A Multicellular Organism Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Tumor Necrosis Factor Nucleoplasm Muscle Cell Differentiation Negative Regulation Of Protein Localization To Lysosome Histone H3K9 Acetyltransferase Activity Carbohydrate Biosynthetic Process Negative Regulation Of Small Molecule Metabolic Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage TRNA (guanine-N7)-methylation Response To Tumor Necrosis Factor Cellular Response To Rapamycin Glucose Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Nucleus