BCL9 and PYGO2

Number of citations of the paper that reports this interaction (PMID 11955446)
103

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		BCL9	PYGO2
Gene Name		B-cell CLL/lymphoma 9	pygopus family PHD finger 2
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Cis-Golgi Network	Nucleoplasm
	Molecular Function	Protein Binding Beta-catenin Binding	Chromatin Binding Protein Binding Zinc Ion Binding Histone Acetyltransferase Regulator Activity Histone Binding
	Biological Process	Myotube Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Somatic Stem Cell Maintenance Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway	In Utero Embryonic Development Kidney Development Lens Development In Camera-type Eye Spermatid Nucleus Differentiation Brain Development Post-embryonic Development Mammary Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Histone Acetylation Positive Regulation Of Chromatin Binding Developmental Growth Regulation Of Histone H3-K4 Methylation Palate Development Canonical Wnt Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer deactivation of the beta-catenin transactivating complex	misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer deactivation of the beta-catenin transactivating complex
Drugs
Diseases
GWAS		Schizophrenia (negative symptoms) ( 23382809)	Prostate cancer ( 23535732)
Protein-Protein Interactions		3 interactors: CTNNB1 PYGO1 PYGO2	5 interactors: BCL9 KAT2A NF2 SUPT3H TRRAP
Entrez ID		607	90780
HPRD ID		04000	06065
Ensembl ID		ENSG00000116128	ENSG00000163348
Uniprot IDs		O00512 Q1JQ81	Q5T170 Q9BRQ0
PDB IDs		2GL7 2VP7 2VPB 2VPD 2VPE 2VPG 3SL9	2XB1
Enriched GO Terms of Interacting Partners?		Germ Cell Development Wnt Signaling Pathway Kidney Development Regulation Of Histone H3-K4 Methylation Renal System Development Spermatid Nucleus Differentiation Urogenital System Development Regulation Of Histone Methylation Gamete Generation Developmental Process Involved In Reproduction Sexual Reproduction Multicellular Organismal Reproductive Process Canonical Wnt Signaling Pathway Multicellular Organism Reproduction Lens Development In Camera-type Eye Nucleus Organization Regulation Of Histone Modification Reproduction Spermatid Development Post-embryonic Development Spermatid Differentiation Single Organism Reproductive Process Reproductive Process Regulation Of Chromosome Organization Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Oviduct Development Regulation Of Centriole-centriole Cohesion Regulation Of Epithelial Cell Proliferation Positive Regulation Of Determination Of Dorsal Identity Lung Induction Embryonic Skeletal Limb Joint Morphogenesis Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Cell Development Central Nervous System Vasculogenesis Trachea Formation Positive Regulation Of Chromatin Binding Cellular Response To Indole-3-methanol Regulation Of Centromeric Sister Chromatid Cohesion Renal Vesicle Formation Camera-type Eye Development	Histone Deubiquitination Protein Deubiquitination Histone Acetylation Internal Peptidyl-lysine Acetylation Protein Modification By Small Protein Removal Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Peptidyl-lysine Modification Histone H3 Acetylation Histone Modification Histone H4 Acetylation Chromatin Modification Chromatin Organization Regulation Of Protein Stability Regulation Of Gene Expression Myotube Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Nitrogen Compound Metabolic Process Peptidyl-amino Acid Modification Chromosome Organization Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Histone H3-K14 Acetylation Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Schwann Cell Proliferation Telencephalon Development Organelle Organization Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Hippo Signaling Histone H4-K12 Acetylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Histone H2A Acetylation Glial Cell Proliferation Regulation Of Metabolic Process Forebrain Development Tissue Development Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Gluconeogenesis Growth Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of JAK-STAT Cascade Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Ectoderm Development
Tagcloud ?		anchor assistance benzimidazole benzothiazoles cleft crystallography discovered displaces docks emanating facilitating finger h3k4me hd1 interface ligandability methylated oncogenesis phd pocket privileged pygo reader relies scaffold surfaces tail template uncovers	catenin compartment converge depilation dispensable emerged epithelia excessive facilitates follicle hair holds homeobox homolog hyperactivation hyperplasia keratinocytes lhx2 lim maximizes prime progenitor prominent promise pygopus regeneration stem trichofolliculoma wnt
Tagcloud (Difference) ?		anchor assistance benzimidazole benzothiazoles cleft crystallography discovered displaces docks emanating facilitating finger h3k4me hd1 interface ligandability methylated oncogenesis phd pocket privileged pygo reader relies scaffold surfaces tail template uncovers	catenin compartment converge depilation dispensable emerged epithelia excessive facilitates follicle hair holds homeobox homolog hyperactivation hyperplasia keratinocytes lhx2 lim maximizes prime progenitor prominent promise pygopus regeneration stem trichofolliculoma wnt
Tagcloud (Intersection) ?