TICRR and TOPBP1

Number of citations of the paper that reports this interaction (PMID 21700459)
19

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TICRR	TOPBP1
Gene Name		TOPBP1-interacting checkpoint and replication regulator	topoisomerase (DNA) II binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Chromosome Cytoplasm Golgi Apparatus Centrosome Actin Cytoskeleton PML Body
	Molecular Function	Chromatin Binding Protein Binding	DNA Binding Protein Binding Protein C-terminus Binding Identical Protein Binding
	Biological Process	Cell Cycle Checkpoint Formation Of Translation Preinitiation Complex DNA Replication DNA Repair Response To Ionizing Radiation Regulation Of DNA-dependent DNA Replication Initiation Mitotic DNA Replication Checkpoint	DNA Metabolic Process DNA Repair Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation
Pathways
Drugs
Diseases
GWAS			Iron status biomarkers ( 19084217)
Protein-Protein Interactions		2 interactors: APP TOPBP1	19 interactors: ABL1 AKT1 ATM BLM BMPR2 BRIP1 CHEK1 CLSTN1 E2F1 PML POLE PPP1CC RAD9A TBC1D4 TCFL5 TICRR TOP2B UBR5 ZBTB17
Entrez ID		90381	11073
HPRD ID		11357	09678
Ensembl ID		ENSG00000140534	ENSG00000163781
Uniprot IDs		Q7Z2Z1	A0AV47 A7E2X7 Q05BV8 Q92547
PDB IDs			1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Response To Radiation Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Neuron Remodeling Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Abiotic Stimulus Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Neuron Recognition RNA Polyadenylation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Neuron Apoptotic Process Regulation Of Protein Tyrosine Kinase Activity Visual Learning Glutamate Receptor Signaling Pathway Visual Behavior Neuron Death Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuromuscular Process Controlling Balance Synapse Assembly MRNA 3'-end Processing Regulation Of ERBB Signaling Pathway Associative Learning Developmental Cell Growth Regulation Of Synapse Structure Or Activity Feeding Behavior Regulation Of Multicellular Organism Growth RNA 3'-end Processing Cholesterol Metabolic Process Adult Locomotory Behavior Positive Regulation Of Mitotic Cell Cycle	Mitotic Cell Cycle Cell Cycle Checkpoint Cellular Response To Stress Mitotic Cell Cycle Process Cell Cycle Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle DNA Damage Checkpoint Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint DNA Repair Regulation Of Response To DNA Damage Stimulus Response To Radiation DNA Metabolic Process Mitotic Cell Cycle Checkpoint Cellular Nitrogen Compound Metabolic Process Response To Stress Negative Regulation Of DNA Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Damage Induced Protein Phosphorylation Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Response To Abiotic Stimulus DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Ionizing Radiation Regulation Of Organelle Organization Cellular Macromolecule Biosynthetic Process Intrinsic Apoptotic Signaling Pathway Macromolecule Biosynthetic Process Negative Regulation Of DNA Biosynthetic Process Cellular Response To Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Proliferation Regulation Of Cell Cycle Phase Transition Biosynthetic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Double-strand Break Repair Regulation Of Cell Cycle Process Positive Regulation Of Signal Transduction G2 DNA Damage Checkpoint Cellular Response To Radiation Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Apoptotic Process
Tagcloud ?		acts assembly cdc45 checkpoint cmg depletion firing gins holohelicase integrate interacting interacts interfering irrespective mcm mdm means mtbp origin ortholog preventing propose replication sld3 stimulating throughout topbp1 treslin yeast	abrogates atr bona checkpoint chk1 clamp claspin damaging extensively fide heterotetrameric hus1 impacting irradiation lac laco lacr lastly localizes onto orphan portion rad1 rad9 repeats repressor rhino tethering uv
Tagcloud (Difference) ?		acts assembly cdc45 cmg depletion firing gins holohelicase integrate interacting interacts interfering irrespective mcm mdm means mtbp origin ortholog preventing propose replication sld3 stimulating throughout treslin yeast	abrogates atr bona chk1 clamp claspin damaging extensively fide heterotetrameric hus1 impacting irradiation lac laco lacr lastly localizes onto orphan portion rad1 rad9 repeats repressor rhino tethering uv
Tagcloud (Intersection) ?		checkpoint topbp1