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C5orf30 and MAPK7
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
C5orf30
MAPK7
Gene Name
chromosome 5 open reading frame 30
mitogen-activated protein kinase 7
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Ciliary Transition Zone
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
PML Body
Molecular Function
Protein Binding
MAP Kinase Activity
Protein Binding
ATP Binding
Mitogen-activated Protein Kinase Binding
Biological Process
Protein Transport
Cilium Morphogenesis
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Cell Cycle
Signal Transduction
Peptidyl-serine Phosphorylation
CAMP-mediated Signaling
Cell Differentiation
Negative Regulation Of CAMP Catabolic Process
Negative Regulation Of Heterotypic Cell-cell Adhesion
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Innate Immune Response
Regulation Of Angiogenesis
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Neurotrophin TRK Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Stress-activated MAPK Cascade
Negative Regulation Of NFAT Protein Import Into Nucleus
Negative Regulation Of Response To Cytokine Stimulus
Cellular Response To Hydrogen Peroxide
Cellular Response To Growth Factor Stimulus
Cellular Response To Laminar Fluid Shear Stress
Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Endothelial Cell Apoptotic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Signaling by GPCR
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cellular Senescence
ERKs are inactivated
Toll Like Receptor TLR6:TLR2 Cascade
Toll Like Receptor TLR1:TLR2 Cascade
Activated TLR4 signalling
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
Gastrin-CREB signalling pathway via PKC and MAPK
MyD88 dependent cascade initiated on endosome
MyD88:Mal cascade initiated on plasma membrane
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Toll Like Receptor 9 (TLR9) Cascade
ERK/MAPK targets
Innate Immune System
Signalling to ERK5
ERKs are inactivated
Signalling by NGF
TRIF-mediated TLR3/TLR4 signaling
MAP kinase activation in TLR cascade
Senescence-Associated Secretory Phenotype (SASP)
NGF signalling via TRKA from the plasma membrane
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
Toll Like Receptor 3 (TLR3) Cascade
ERK/MAPK targets
Toll Like Receptor 4 (TLR4) Cascade
MAPK targets/ Nuclear events mediated by MAP kinases
Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Rheumatoid arthritis (
20453842
)
Protein-Protein Interactions
4 interactors:
MAPK7
MDFI
PNMA1
TRAF1
27 interactors:
ACTN4
APP
C5orf30
EGLN3
ELK4
ETS1
FGF21
FOS
GJA1
GOLGB1
MAP2K5
MEF2A
MEF2C
MEF2D
MYC
NFE2L2
NR1I2
PRKCZ
PTPRR
RAF1
RXRA
SGK1
SH2D2A
UBE2C
YWHAB
YWHAE
ZBED6CL
Entrez ID
90355
5598
HPRD ID
12383
03952
Ensembl ID
ENSG00000181751
ENSG00000166484
Uniprot IDs
Q96GV9
Q13164
PDB IDs
2Q8Y
4B99
4IC7
4IC8
Enriched GO Terms of Interacting Partners
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Negative Regulation Of Transcription Factor Import Into Nucleus
Negative Regulation Of Protein Import Into Nucleus
Negative Regulation Of Protein Localization To Nucleus
Negative Regulation Of Intracellular Protein Transport
Regulation Of Transcription Factor Import Into Nucleus
Negative Regulation Of Intracellular Transport
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Regulation Of Protein Import Into Nucleus
Negative Regulation Of CAMP Catabolic Process
Negative Regulation Of Protein Transport
Regulation Of Protein Localization To Nucleus
Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Nucleocytoplasmic Transport
MAPK Cascade
Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Regulation Of Intracellular Protein Transport
Signal Transduction By Phosphorylation
Regulation Of Apoptotic Process
Regulation Of Cell Death
Negative Regulation Of NFAT Protein Import Into Nucleus
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Heterotypic Cell-cell Adhesion
Negative Regulation Of Transport
Regulation Of Intracellular Transport
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Cellular Response To Fluid Shear Stress
Response To Laminar Fluid Shear Stress
Trophoblast Giant Cell Differentiation
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Cytoplasmic Sequestering Of Transcription Factor
Dorsal/ventral Axis Specification
CAMP-mediated Signaling
Regulation Of Protein Transport
Cytoplasmic Sequestering Of Protein
Negative Regulation Of Endothelial Cell Apoptotic Process
Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Oxidative Stress-induced Cell Death
Regulation Of Establishment Of Protein Localization
Cyclic-nucleotide-mediated Signaling
Cell Differentiation Involved In Embryonic Placenta Development
Negative Regulation Of CAMP Metabolic Process
Inflammatory Response To Antigenic Stimulus
Regulation Of Endothelial Cell Apoptotic Process
Regulation Of Signal Transduction
Activation Of JUN Kinase Activity
Regulation Of Gastrulation
Response To Fluid Shear Stress
Regulation Of Protein Localization
Negative Regulation Of Nucleotide Metabolic Process
Response To Fluid Shear Stress
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Cellular Metabolic Process
Apoptotic Process
Programmed Cell Death
Cellular Response To Growth Factor Stimulus
Cell Death
Death
Positive Regulation Of Metabolic Process
Response To Growth Factor
Negative Regulation Of Cellular Metabolic Process
Regulation Of Apoptotic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Fluid Shear Stress
Regulation Of Cell Death
Positive Regulation Of Protein Metabolic Process
Regulation Of Metabolic Process
MAPK Cascade
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Response To Organic Substance
Positive Regulation Of Behavioral Fear Response
Regulation Of Transcription From RNA Polymerase II Promoter
Transcription From RNA Polymerase II Promoter
Regulation Of Phosphorus Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Cellular Response To Organic Substance
Positive Regulation Of Macromolecule Biosynthetic Process
Signal Transduction By Phosphorylation
Positive Regulation Of Gene Expression
Regulation Of Cellular Component Organization
Cellular Response To Stimulus
Positive Regulation Of Cellular Biosynthetic Process
Response To Stress
Positive Regulation Of Transcription, DNA-templated
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Neurotrophin Signaling Pathway
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Cell Proliferation
Cardiac Conduction
Regulation Of Signal Transduction
Cardiovascular System Development
Regulation Of RNA Metabolic Process
Regulation Of MAPK Cascade
Learning Or Memory
Anatomical Structure Morphogenesis
Signal Transduction
Response To Hormone
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