UCN2 and IL10RB

Number of citations of the paper that reports this interaction (PMID 11416224)
149

Data Source:
HPRD (in vitro)

		UCN2	IL10RB
Gene Name		urocortin 2	interleukin 10 receptor, beta
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Integral Component Of Membrane Interleukin-28 Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Receptor Binding Receptor Binding Hormone Activity Hormone Binding Corticotropin-releasing Hormone Receptor 2 Binding	Receptor Activity Interleukin-10 Receptor Activity Protein Binding
	Biological Process	CAMP Biosynthetic Process Response To Stress Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Digestion Cell Proliferation Negative Regulation Of Gene Expression Cellular Response To Nutrient Levels Negative Regulation Of Luteinizing Hormone Secretion Response To Immobilization Stress Negative Regulation Of Follicle-stimulating Hormone Secretion Cellular Response To Glucocorticoid Stimulus Cellular Response To Hypoxia	Inflammatory Response Immune Response Signal Transduction Cytokine-mediated Signaling Pathway Defense Response To Virus
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Crohn's disease ( 23128233)
Protein-Protein Interactions		2 interactors: CRHR2 IL10RB	7 interactors: IFNL2 IFNL3 IL10 IL10RA IL22 UCN2 UCN3
Entrez ID		90226	3588
HPRD ID		16171	00473
Ensembl ID		ENSG00000145040	ENSG00000243646
Uniprot IDs		Q96RP3	Q08334
PDB IDs		2RMG 3N95	3LQM
Enriched GO Terms of Interacting Partners?		Cellular Response To Corticotropin-releasing Hormone Stimulus Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of CAMP-mediated Signaling Regulation Of CAMP-mediated Signaling	Response To Glucocorticoid Response To Corticosteroid Response To Lipid Response To External Stimulus Response To Steroid Hormone Response To Immobilization Stress Response To Other Organism Response To Biotic Stimulus Signaling Cell Communication Response To Stress Response To Organic Cyclic Compound Response To Hormone JAK-STAT Cascade Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Organic Substance Negative Regulation Of Interferon-alpha Biosynthetic Process Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Defense Response Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Digestion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Response To Stimulus Regulation Of Secretion G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Defense Response To Virus Negative Regulation Of Secretion By Cell Negative Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Luteinizing Hormone Secretion Response To Carbon Monoxide Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of Secretion Cellular Response To Nutrient Levels Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Protein Secretion Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of B Cell Apoptotic Process Regulation Of Immune Response Cellular Response To Extracellular Stimulus Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of MHC Class II Biosynthetic Process Regulation Of Myeloid Dendritic Cell Activation Receptor Biosynthetic Process Cytoplasmic Sequestering Of NF-kappaB Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of Gonadotropin Secretion Negative Regulation Of Cytokine Secretion Involved In Immune Response
Tagcloud ?		agonists belonging cardioprotection cardiovascular congestive corticotropin crh exert gastrointestinal gpcr hormones inotropic lusitropic nervous r1 r2 releasing renin reperfusion reproductive restoration summarizes suppress sympathetic ucn1 ucn3 urocortins vasodilation	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il11ra il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Difference) ?		agonists belonging cardioprotection cardiovascular congestive corticotropin crh exert gastrointestinal gpcr hormones inotropic lusitropic nervous r1 r2 releasing renin reperfusion reproductive restoration summarizes suppress sympathetic ucn1 ucn3 urocortins vasodilation	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il11ra il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Intersection) ?