NAT1 and NAA10

Number of citations of the paper that reports this interaction (PMID 12888564)
17

Data Source:
HPRD (in vitro, in vivo)

		NAT1	NAA10
Gene Name		N-acetyltransferase 1 (arylamine N-acetyltransferase)	N(alpha)-acetyltransferase 10, NatA catalytic subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Intracellular Nucleus Nucleolus Cytoplasm Membrane Cytosolic Ribosome NatA Complex
	Molecular Function	Arylamine N-acetyltransferase Activity	Peptide Alpha-N-acetyltransferase Activity Protein Binding N-acetyltransferase Activity Acetyltransferase Activity Ribosome Binding Peptide-serine-N-acetyltransferase Activity Peptide-glutamate-N-acetyltransferase Activity
	Biological Process	Xenobiotic Metabolic Process Small Molecule Metabolic Process	DNA Packaging N-terminal Protein Amino Acid Acetylation Internal Protein Amino Acid Acetylation N-terminal Peptidyl-serine Acetylation N-terminal Peptidyl-glutamic Acid Acetylation
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Acetylation Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: NAA10 SNTA1	24 interactors: BCOR CALCOCO2 CDC25A CEP44 EHMT2 FIP1L1 HIF1A KIFAP3 KRTAP10-3 KRTAP10-5 KRTAP10-7 MEOX2 NAA15 NAA16 NAA50 NAT1 NAT2 PDE4DIP PSME2 RAB3IP RBCK1 RPL26 SSX2IP ZBTB14
Entrez ID		9	8260
HPRD ID		00149	02056
Ensembl ID		ENSG00000171428
Uniprot IDs		F5H5R8 P18440 Q400J6	B4DKJ7 B7Z9N2 P41227
PDB IDs		2DSS 2GWU 2IJA 2PQT
Enriched GO Terms of Interacting Partners?		Regulation Of Vasoconstriction By Circulating Norepinephrine N-terminal Peptidyl-serine Acetylation N-terminal Peptidyl-glutamic Acid Acetylation Negative Regulation Of Peptidyl-cysteine S-nitrosylation N-terminal Protein Amino Acid Acetylation Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization N-terminal Protein Amino Acid Modification Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Neuromuscular Junction Development Regulation Of Vasoconstriction Regulation Of Sodium Ion Transport Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Action Potential Internal Protein Amino Acid Acetylation Protein Acetylation Regulation Of Muscle Contraction Regulation Of Heart Contraction Synapse Organization DNA Packaging Muscle Contraction Muscle System Process Regulation Of Membrane Potential DNA Conformation Change	N-terminal Protein Amino Acid Acetylation N-terminal Protein Amino Acid Modification Protein Acetylation Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Protein Stabilization Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Process Negative Regulation Of Bone Mineralization Negative Regulation Of Biomineral Tissue Development Regulation Of Cell Death Microtubule-based Transport Regulation Of Protein Stability Cytoskeleton-dependent Intracellular Transport Cellular Protein Modification Process Neutral Amino Acid Transport Negative Regulation Of Histone H3-K36 Methylation Mitotic Sister Chromatid Cohesion, Centromeric Neural Fold Elevation Formation Positive Regulation Of Calcium-dependent Cell-cell Adhesion Viral Process Cellular Protein Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Regulation Of Bone Mineralization Negative Regulation Of Tooth Mineralization Elastin Metabolic Process Protein Metabolic Process Negative Regulation Of Ossification Microtubule-based Movement Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Protein Linear Polyubiquitination Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development DNA Methylation On Cytosine Within A CG Sequence Intestinal Epithelial Cell Maturation Cellular Nitrogen Compound Metabolic Process Palate Development Positive Regulation Of Transcription, DNA-templated Histone Modification Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Specification Of Axis Polarity Norepinephrine Transport Amino Acid Transmembrane Transport Gene Expression Regulation Of Transcription, DNA-templated
Tagcloud ?		4g aberrant alters apobec apolipoprotein binds cap carboxy codons creates dysplasia edited editing eif4a eif4e eif4f encoded extensively extraordinarily fundamental homology livers oncogenesis portion rabbit repressor stop transgene ubiquitously	00e 19e 40e 47e asian autosomes cohorts contributors erythematosus gwas han intriguing irak1 l1cam mecp2 predisposition predominance prototype prototypic prps2 replicated replicating rs1059702 rs17422 rs2071128 rs7062536 sle tmem187 xp22
Tagcloud (Difference) ?		4g aberrant alters apobec apolipoprotein binds cap carboxy codons creates dysplasia edited editing eif4a eif4e eif4f encoded extensively extraordinarily fundamental homology livers oncogenesis portion rabbit repressor stop transgene ubiquitously	00e 19e 40e 47e asian autosomes cohorts contributors erythematosus gwas han intriguing irak1 l1cam mecp2 predisposition predominance prototype prototypic prps2 replicated replicating rs1059702 rs17422 rs2071128 rs7062536 sle tmem187 xp22
Tagcloud (Intersection) ?