NAT1

Gene Name		N-acetyltransferase 1 (arylamine N-acetyltransferase)
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Gene Ontology Annotations	Cellular Component	Cytosol
	Molecular Function	Arylamine N-acetyltransferase Activity
	Biological Process	Xenobiotic Metabolic Process Small Molecule Metabolic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Acetylation Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: NAA10 SNTA1
Entrez ID		9
HPRD ID		00149
Ensembl ID		ENSG00000171428
Uniprot IDs		F5H5R8 P18440 Q400J6
PDB IDs		2DSS 2GWU 2IJA 2PQT
Enriched GO Terms of Interacting Partners?		Regulation Of Vasoconstriction By Circulating Norepinephrine N-terminal Peptidyl-serine Acetylation N-terminal Peptidyl-glutamic Acid Acetylation Negative Regulation Of Peptidyl-cysteine S-nitrosylation N-terminal Protein Amino Acid Acetylation Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization N-terminal Protein Amino Acid Modification Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Neuromuscular Junction Development Regulation Of Vasoconstriction Regulation Of Sodium Ion Transport Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Action Potential Internal Protein Amino Acid Acetylation Protein Acetylation Regulation Of Muscle Contraction Regulation Of Heart Contraction Synapse Organization DNA Packaging Muscle Contraction Muscle System Process Regulation Of Membrane Potential DNA Conformation Change
Tagcloud ?		4g aberrant alters apobec apolipoprotein binds cap carboxy codons creates dysplasia edited editing eif4a eif4e eif4f encoded extensively extraordinarily fundamental homology livers oncogenesis portion rabbit repressor stop transgene ubiquitously