UBE3B and CDC34

Number of citations of the paper that reports this interaction (PubMedID 33298911)
55

Data Source:
BioGRID (pull down)

		UBE3B	CDC34
Description		ubiquitin protein ligase E3B	cell division cycle 34, ubiquitin conjugating enzyme
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Postsynaptic Density Synapse Postsynapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Postsynapse Assembly	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Replication Initiation Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cellular Response To Interferon-beta Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Downstream TCR signaling FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Coronary artery disease ( 32469254) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 20864672) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817) Mean corpuscular hemoglobin ( 32888494) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Polymyositis ( 26362759) Pork consumption ( 32066663) PR interval ( 32439900) Total cholesterol levels ( 30275531 33339817)
Interacting Genes		8 interacting genes: CDC34 EPAS1 HIF1A HRAS MYC UBE2N UBE2V1 UBE2V2	60 interacting genes: ATF5 BTRC CCNB1 CDK9 CDKN1B CREM CSNK2B CUL1 CUL2 CUL3 DIABLO EGFR FBXL2 FBXL3 FBXO32 FBXO4 FBXO7 FBXW2 FBXW7 HIF1A ING4 ITCH MARCHF1 MARCHF2 MDM2 MEOX1 MEOX2 MUL1 MYBL2 MYOD1 NEDD4L NEDD8 NFKBIA PPARA PPARG PTTG1 RAG1 RBX1 RELA RNF167 RNF31 RNF7 ROCK1 SDCBP SIAH1 SKP2 TBL1X TRIM13 TRIM21 TRIM28 TRIM29 UBB UBC UBE3B USP2 USP21 VHL WWP2 ZFAND6 ZNRF1
Entrez ID		89910	997
HPRD ID		06993	00306
Ensembl ID		ENSG00000151148	ENSG00000099804
Uniprot IDs		Q7Z3V4	P49427
PDB IDs			2OB4 3RZ3 4MDK 7M2K 8RX0
Enriched GO Terms of Interacting Partners?		UBC13-MMS2 Complex Ubiquitin Conjugating Enzyme Complex Positive Regulation Of Protein K63-linked Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Polyubiquitination Error-free Postreplication DNA Repair Regulation Of Protein Polyubiquitination Ubiquitin Conjugating Enzyme Activity Postreplication Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MiRNA Metabolic Process Regulation Of Protein Modification Process Protein K63-linked Ubiquitination Protein Polyubiquitination Cis-regulatory Region Sequence-specific DNA Binding Nucleoplasm Regulation Of MiRNA Metabolic Process Intracellular Oxygen Homeostasis Positive Regulation Of Protein Ubiquitination Cellular Response To Stress Positive Regulation Of Post-translational Protein Modification Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Protein Neddylation Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Oxygen Levels Response To Stress Regulation Of DNA Metabolic Process Epithelial Cell Maturation DNA Double-strand Break Processing Nucleic Acid Metabolic Process Embryonic Placenta Development Regulation Of Cellular Response To Stress Protein Dimerization Activity Regulation Of Protein Ubiquitination Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Metabolic Process Protein Ubiquitination Regulation Of DNA Repair Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription Coactivator Binding Regulation Of Protein Metabolic Process Protein-containing Complex Positive Regulation Of DNA Metabolic Process DNA Damage Response Response To Hypoxia	Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Proteolysis Macromolecule Catabolic Process Protein Polyubiquitination Protein Catabolic Process SCF Ubiquitin Ligase Complex Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Metabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Catabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Catabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Cytosol Protein Destabilization Regulation Of Protein Stability Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Regulation Of RNA Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Autophagy G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Autophagy Cell Cycle G1/S Phase Transition Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Intracellular Signal Transduction
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