CDCA2 and PPP1CA

Number of citations: 76 (PubMedID 29764992)
Data Source: BioGRID (pull down)

		CDCA2	PPP1CA
Name		cell division cycle associated 2	protein phosphatase 1 catalytic subunit alpha
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol	Protein Phosphatase Type 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Adherens Junction Glycogen Granule Neuronal Cell Body Dendritic Spine Perikaryon Extracellular Exosome PTW/PP1 Phosphatase Complex Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Phosphatase Regulator Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Iron Ion Binding Protein Binding Protein Phosphatase 1 Binding Hydrolase Activity Phosphatase Activity Ribonucleoprotein Complex Binding Protein-containing Complex Binding Metal Ion Binding Transition Metal Ion Binding Cadherin Binding Involved In Cell-cell Adhesion RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity
	Biological Process	Chromosome Segregation Regulation Of Mitotic Nuclear Division Cell Division	Telomere Maintenance RNA Polymerase II Promoter Clearance Glycogen Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Glycogen Catabolic Process Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Protein Dephosphorylation Response To Lead Ion Dephosphorylation Lung Development Circadian Regulation Of Gene Expression Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Telomere Maintenance In Response To DNA Damage Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Glycogen Biosynthetic Process Branching Morphogenesis Of An Epithelial Tube Protein Stabilization Cell Division Regulation Of Canonical Wnt Signaling Pathway Double-strand Break Repair Via Alternative Nonhomologous End Joining Cell-cell Adhesion Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		None	Triglyceride catabolism DARPP-32 events Downregulation of TGF-beta receptor signaling Maturation of hRSV A proteins Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
Drugs		None	2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
GWAS		Appendicular lean mass ( 33097823 ) HDL cholesterol levels ( 32203549 ) Hip index ( 34021172 ) Major depressive disorder ( 27479909 ) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306 ) Systolic blood pressure x quantitative lifestyle risk score interaction (1df test) ( 32227373 ) Systolic blood pressure x quantitative lifestyle risk score interaction (2df test) ( 32227373 ) Triglyceride levels ( 32203549 ) Visceral adipose tissue volume ( 34128465 )	Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Height ( 28552196 )
Novel Interactors		None recorded	2 novel interactors: ATP5MG RELA
Interacting Genes		4 interacting genes: CDK1 MBD4 PPP1CA PPP2R5A	173 interacting genes: AATK AHCTF1 AKAP1 AKAP11 AKAP9 AKT1 APAF1 ASPM AURKA BAD BAX BCL2 BCL2L1 BCL2L2 BRCA1 BTBD10 C1QA CAD CAV1 CCDC181 CDC5L CDCA2 CDH1 CEP126 CEP170 CEP192 CKB CLCN2 CLOCK CNP CNST CNTN1 CREB1 CRK CSNK1E CSNK2B CSRNP1 CSRNP2 CUL1 CXXC1 DCTN1 DCX DEAF1 DELEC1 DYNLT4 EED EIF2AK2 ESR1 FRMPD4 FXYD1 GLIPR1L2 GPKOW H2AX H3-3A H3C1 HEYL HSPA4 IBTK ID2 ITGB8 JPH3 KANK1 KCNQ1 KCTD20 KIF13A KIF18A KNL1 LMTK2 LPIN2 MAFG MAL2 MAP4K4 MAPK1 MAPK3 MAPT MECOM MIIP MKI67 MPHOSPH10 MST1R MYO16 NCAM1 NDP NEDD8 NEK2 NOC2L NOM1 NONO NOP53 PAK1 PBK PCDH7 PCNA PHACTR1 PHACTR3 PHACTR4 PHB2 PHC1 PIAS1 PIAS3 PLCL2 POLR2A PPP1R10 PPP1R11 PPP1R13B PPP1R13L PPP1R15A PPP1R15B PPP1R16A PPP1R18 PPP1R1B PPP1R2 PPP1R26 PPP1R27 PPP1R2B PPP1R2C PPP1R37 PPP1R3B PPP1R3C PPP1R3D PPP1R3E PPP1R3G PPP1R8 PPP1R9A PPP1R9B PPP2CA PPP2R5C PPP2R5E PREX1 PRKCB PRKCD PRR16 PTEN PTPN7 PYGM RANBP9 RB1 RORC RPRD2 RRP1B SAXO4 SEH1L SFI1 SFRP1 SH3RF2 SKP1 SLC45A1 SORL1 SPRED1 STAM STAU1 SYTL2 TOE1 TOR1AIP1 TOX4 TP53 TP53BP2 TPRN TRIM21 TSC2 TUSC3 UBC UBE2Z UBR5 ULK1 VDR WBP11 WDR82 YLPM1 ZBTB11 ZFYVE16 ZFYVE9 ZNF827
Entrez ID		157313	5499
HPRD ID		13014	15942
Ensembl ID		ENSG00000184661	ENSG00000172531
Uniprot IDs		A8K8Z0 B7Z5Q5 E9PEI0 Q69YH5	A0A140VJS9 P62136
PDB IDs		5INB 5IOH 5SW9	3E7A 3E7B 3EGG 3EGH 3HVQ 3N5U 3V4Y 4G9J 4MOV 4MOY 4MP0 4XPN 5IOH 6ALZ 6CZO 6DCX 6DNO 6G0I 6G0J 6GHM 6OBN 6OBP 6OBQ 6OBR 6OBS 6OBU 6ZEE 6ZEF 6ZEG 6ZEH 6ZEI 6ZEJ 6ZK6 7QFB 7QM2 7T0Y 7TVF 7TXH 7UPI 8DWK 8DWL 8SW5 8SW6 8U5G
GO Terms Enriched among Interactors		DNA Metabolic Process Pronuclear Fusion Regulation Of Circadian Rhythm Mitotic DNA-templated DNA Replication DNA Damage Response DNA Repair Cyclin B1-CDK1 Complex Pyrimidine-containing Compound Metabolic Process Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Regulation Of Generation Of Precursor Metabolites And Energy RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Chromosome, Telomeric Region Cyclin-dependent Protein Kinase Activity Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Regulation Of Schwann Cell Differentiation Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription Satellite DNA Binding Thymidine Metabolic Process Golgi Disassembly Nuclear DNA Replication Rhythmic Process Thymidine Biosynthetic Process Histone Kinase Activity Glycogen Granule PTW/PP1 Phosphatase Complex Kinase Inhibitor Activity Phosphate-containing Compound Metabolic Process RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Depyrimidination Response To Metal Ion Positive Regulation Of Mitotic Sister Chromatid Segregation RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Chromosome Organization Ventricular Cardiac Muscle Cell Development Regulation Of Translational Initiation In Response To Stress Double-strand Break Repair Via Alternative Nonhomologous End Joining Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand DNA N-glycosylase Activity Mitotic Nuclear Membrane Disassembly Cilium Disassembly Cellular Response To Stress Pyrimidine Nucleoside Metabolic Process	Protein Phosphatase 1 Binding Protein Phosphatase Inhibitor Activity Phosphatase Binding Intracellular Signal Transduction Protein Phosphatase Regulator Activity Protein Phosphatase Type 1 Complex Negative Regulation Of Intracellular Signal Transduction Apoptotic Process Programmed Cell Death Cell Death Regulation Of Cell Cycle Enzyme Binding Regulation Of Intracellular Signal Transduction Nucleoplasm Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Intrinsic Apoptotic Signaling Pathway Nucleus Glycogen Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Glycogen Binding Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Cytoplasm Positive Regulation Of Metabolic Process Polysaccharide Metabolic Process Energy Reserve Metabolic Process Cell Population Proliferation Release Of Cytochrome C From Mitochondria Chromosome Response To Radiation Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of Programmed Cell Death Response To Starvation Regulation Of Glycogen Biosynthetic Process Protein Localization To Organelle Negative Regulation Of Apoptotic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Protein Metabolic Process Signal Transduction Cellular Response To Oxygen-containing Compound Response To Light Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Bcl-2 Family Protein Complex