EIF2B3 and IPO13

		EIF2B3	IPO13
Description		eukaryotic translation initiation factor 2B subunit gamma	importin 13
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GO Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Nucleus Cytoplasm
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Factor Activity, RNA Binding	Protein Binding Small GTPase Binding
	Biological Process	Cytoplasmic Translational Initiation Translation Translational Initiation Central Nervous System Development Response To Heat Response To Glucose Oligodendrocyte Development Response To Peptide Hormone T Cell Receptor Signaling Pathway	Protein Import Into Nucleus Intracellular Protein Transport Protein Transport
Pathways		Recycling of eIF2:GDP
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Diseases		Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Platelet distribution width ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		5 interacting genes: EIF2S1 EIF2S2 GOLM1 NDUFB8 STC2	20 interacting genes: ALX1 ARX CRX EIF1AX GK HMBOX1 MAGOH NOSIP NPSR1 NUP50 PAX3 PAX6 PBX4 PITX1 PSMA1 RAN RBM8A RNF10 RPL5 UBE2I
Entrez ID		8891	9670
HPRD ID		09379	13742
Ensembl ID		ENSG00000070785	ENSG00000117408
Uniprot IDs		Q9HA31 Q9NR50	O94829
PDB IDs		6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z 7D43 7D44 7D45 7D46 7F64 7F66 7F67 7KMF 7L70 7L7G 7RLO 7TRJ 7VLK 8TQO 8TQZ	2X19 2XWU 3ZJY
Enriched GO Terms of Interacting Partners?		Eukaryotic Translation Initiation Factor 2 Complex Endoplasmic Reticulum Unfolded Protein Response Translation Initiation Ternary Complex Translation Initiation Factor Activity Histone H3K36me2/H3K36me3 Demethylase Activity Translational Initiation Response To Manganese-induced Endoplasmic Reticulum Stress Glial Limiting End-foot N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Male Germ Cell Proliferation	Translation Initiation Factor Activity Chromatin Translational Initiation Exon-exon Junction Subcomplex Mago-y14 Cytosol Sequence-specific Double-stranded DNA Binding Nuclear Export Nuclear Transport Nucleocytoplasmic Transport RNA Transport RNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Neuron Development Translation Eukaryotic 48S Preinitiation Complex Eukaryotic 43S Preinitiation Complex RNA Export From Nucleus Nuclear Pore Nucleobase-containing Compound Transport Translation Factor Activity, RNA Binding Exon-exon Junction Complex Cell Development Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Nucleoplasm Pronuclear Fusion Regulation Of Macromolecule Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Chromatin Binding Cytoplasm Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process MRNA Transport Sequence-specific DNA Binding Forebrain-midbrain Boundary Formation Pituitary Gland Development Pancreatic A Cell Development SUMO Conjugating Enzyme Activity Structural Constituent Of Presynapse Cytoplasmic Translational Initiation
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