EIF2B3 and NDUFB8

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EIF2B3	NDUFB8
Gene Name		eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex	Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Endoplasmic Reticulum Integral Component Of Membrane
	Molecular Function	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Nucleotidyltransferase Activity	NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Translation Translational Initiation Response To Heat Response To Glucose Gene Expression Oligodendrocyte Development Negative Regulation Of Translational Initiation In Response To Stress Response To Peptide Hormone Positive Regulation Of GTPase Activity Cellular Protein Metabolic Process Cellular Response To Stimulus	Mitochondrial Electron Transport, NADH To Ubiquinone Respiratory Electron Transport Chain Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Recycling of eIF2:GDP Translation Eukaryotic Translation Initiation Cap-dependent Translation Initiation	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport
Drugs			NADH
Diseases
GWAS			Palmitoleic acid (16:1n-7) plasma levels ( 23362303)
Protein-Protein Interactions		5 interactors: EIF2S1 EIF2S2 GOLM1 NDUFB8 STC2	6 interactors: ATP6V0D2 CACNA1A EIF2B3 PFN2 PIM2 ZAP70
Entrez ID		8891	4714
HPRD ID		09379	11886
Ensembl ID		ENSG00000070785	ENSG00000166136
Uniprot IDs		Q9HA31 Q9NR50	O95169
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Male Germ Cell Proliferation Translational Initiation Regulation Of Translational Initiation In Response To Stress Regulation Of Translation In Response To Stress	Regulation Of Neurotransmitter Secretion Cerebellar Molecular Layer Development Vestibular Nucleus Development Beta Selection Regulation Of Exocytosis Cerebellum Maturation Musculoskeletal Movement, Spinal Reflex Action Gamma-aminobutyric Acid Secretion Protein Autophosphorylation Regulation Of Acetylcholine Secretion, Neurotransmission Rhythmic Synaptic Transmission Negative Regulation Of Ruffle Assembly Negative Regulation Of Translational Initiation In Response To Stress Calcium Ion-dependent Exocytosis Of Neurotransmitter Cellular Chloride Ion Homeostasis Negative Regulation Of Translation In Response To Stress Gamma-aminobutyric Acid Transport Chloride Ion Homeostasis Regulation Of Synaptic Transmission Positive Thymic T Cell Selection Negative Regulation Of Hormone Biosynthetic Process Regulation Of Translational Initiation In Response To Stress Pons Development Regulation Of Signaling Regulation Of Vesicle-mediated Transport Negative Thymic T Cell Selection Positive Regulation Of Alpha-beta T Cell Proliferation Cerebellar Purkinje Cell Differentiation Negative T Cell Selection Regulation Of Translation In Response To Stress Cellular Metal Ion Homeostasis Cerebellar Purkinje Cell Layer Morphogenesis Regulation Of Ruffle Assembly T Cell Migration Negative Regulation Of Translational Initiation Cellular Cation Homeostasis Cellular Ion Homeostasis Response To Peptide Hormone Posttranscriptional Regulation Of Gene Expression Reflex Metal Ion Homeostasis Behavioral Response To Pain Thymic T Cell Selection Regulation Of Cell Projection Organization Response To Peptide Neuromuscular Synaptic Transmission
Tagcloud ?		1090c 1980s 314a 318a 877c ataxia atrophy compiled deterioration dystonic genetics hemiparesis hereditary leukoencephalopathy list macrocephaly manifestation matter movements necropsy optic spain spasticity suffered vanishing vwm
Tagcloud (Difference) ?		1090c 1980s 314a 318a 877c ataxia atrophy compiled deterioration dystonic genetics hemiparesis hereditary leukoencephalopathy list macrocephaly manifestation matter movements necropsy optic spain spasticity suffered vanishing vwm
Tagcloud (Intersection) ?