CCKBR and PPP1R9B

Number of citations of the paper that reports this interaction (PubMedID 17464283)
34

Data Source:
HPRD (in vitro)

		CCKBR	PPP1R9B
Description		cholecystokinin B receptor	protein phosphatase 1 regulatory subunit 9B
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Protein Phosphatase Type 1 Complex Nucleus Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Adherens Junction Postsynaptic Density Actin Cytoskeleton Membrane Lamellipodium Filopodium Dendrite Growth Cone Cortical Actin Cytoskeleton Ruffle Membrane Dendritic Spine Membrane Cell Projection Neuronal Cell Body Dendritic Spine Dendritic Spine Neck Dendritic Spine Head Synapse Anchoring Junction Spine Apparatus Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse Plasma Membrane Bounded Cell Projection Cytoplasmic Side Of Dendritic Spine Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Activity Cholecystokinin Receptor Activity Protein Binding Neuropeptide Receptor Activity Gastrin Receptor Activity Peptide Hormone Binding Type B Gastrin/cholecystokinin Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Actin Binding Protein Kinase Activity Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding Kinase Binding D2 Dopamine Receptor Binding Transmembrane Transporter Binding Protein-containing Complex Binding Actin Filament Binding
	Biological Process	Gastric Acid Secretion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Positive Regulation Of Cell Population Proliferation Cholecystokinin Signaling Pathway PH Reduction Digestive Tract Development Gland Development	Regulation Of Cell Growth By Extracellular Stimulus Response To Amphetamine Developmental Process Involved In Reproduction Actin Filament Organization Regulation Of Exit From Mitosis Nervous System Development Learning RNA Splicing Response To Xenobiotic Stimulus Dendrite Development Cell Migration Calcium-mediated Signaling Hippocampus Development Cerebral Cortex Development Actin Filament Depolymerization Cell Differentiation Negative Regulation Of Cell Growth Neuron Projection Development Response To Estradiol Response To Prostaglandin E Response To Nicotine Response To Immobilization Stress Regulation Of Cell Population Proliferation Response To Amino Acid Filopodium Assembly Response To Steroid Hormone Regulation Of Cell Cycle Male Mating Behavior Reproductive System Development Cellular Response To Morphine Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Xenobiotic Stimulus Regulation Of Postsynapse Assembly Cellular Response To Peptide Positive Regulation Of Protein Localization To Plasma Membrane Protein Localization To Actin Cytoskeleton Positive Regulation Of Protein Localization Positive Regulation Of Protein Localization To Actin Cortical Patch Response To Kainic Acid Response To L-phenylalanine Derivative Protein Localization To Cell Periphery Regulation Of Opioid Receptor Signaling Pathway
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		Pentagastrin Cholecystokinin
Diseases
GWAS		Diastolic blood pressure ( 30224653) Early spontaneous preterm birth ( 31194736) Gastroesophageal reflux disease ( 31527586) Malaria ( 31844061) Rheumatic heart disease ( 34106200)	Platelet distribution width ( 32888494) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		10 interacting genes: ADRB2 ATP13A2 CCK CCKAR CCR4 DRD2 NTM PPP1R9B PTPN11 SLCO1B3	29 interacting genes: ACTA1 ACTN2 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C CCKAR CCKBR CDKN2A CHRM3 DCX DRD2 ITGB8 LRRC7 MAPK1 MECOM PPP1CA PPP1R2 PPP1R9A PRKACA RB1 RBL1 RBL2 RGS2 RPS6KB1 SHANK3 TGOLN2 TIAM1
Entrez ID		887	84687
HPRD ID		00323	04506
Ensembl ID		ENSG00000110148	ENSG00000108819
Uniprot IDs		E9PIC8 P32239	Q96SB3
PDB IDs		1L4T 7F8V 7F8W 7XOW 8IA7
Enriched GO Terms of Interacting Partners?		Cholecystokinin Signaling Pathway Axonogenesis Neuron Migration Cell Migration Neuron Projection Morphogenesis Cell Projection Morphogenesis Cell Motility Peptide Hormone Receptor Binding Regulation Of Growth Hormone Secretion Interneuron Migration G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Response To Morphine Regulation Of G Protein-coupled Receptor Signaling Pathway Multicellular Organismal-level Homeostasis Response To Amphetamine Temperature Homeostasis Cell Projection Organization Regulation Of Secretion By Cell Potassium Channel Regulator Activity Negative Regulation Of Blood Pressure Regulation Of Secretion Response To Nicotine Response To Amine Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Cellular Response To Epidermal Growth Factor Stimulus Smooth Muscle Contraction Vasodilation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Ossification Homeostatic Process Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of Hormone Secretion Positive Regulation Of Secretion By Cell Regulation Of Protein Secretion Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Response To Epidermal Growth Factor Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane Regulation Of Multicellular Organism Growth Positive Regulation Of Secretion Negative Regulation Of Hormone Secretion Regulation Of Sodium Ion Transport Forebrain Development	Adrenergic Receptor Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adrenergic Receptor Signaling Pathway Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Negative Regulation Of Catecholamine Secretion Alpha2-adrenergic Receptor Activity Regulation Of Muscle System Process Intracellular Signaling Cassette Regulation Of Blood Circulation G Protein-coupled Receptor Activity Signal Transduction Regulation Of System Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Lipid Kinase Activity Intracellular Signal Transduction Negative Regulation Of Epinephrine Secretion Regulation Of Vasoconstriction Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Regulation Of Amine Transport System Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Catecholamine Secretion Regulation Of Biological Quality Regulation Of MAPK Cascade Regulation Of Signal Transduction Regulation Of Norepinephrine Secretion Modulation Of Chemical Synaptic Transmission Positive Regulation Of Muscle Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Developmental Process Phospholipase C-activating Adrenergic Receptor Signaling Pathway Cholecystokinin Receptor Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Hormone Secretion Dendritic Spine Positive Regulation Of Signal Transduction Regulation Of Tube Size Blood Vessel Diameter Maintenance Regulation Of Intracellular Signal Transduction Alpha1-adrenergic Receptor Activity Cholecystokinin Signaling Pathway Regulation Of Insulin Secretion ERBB Signaling Pathway Positive Regulation Of Cellular Component Organization
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