CCKBR and CCKAR

Number of citations of the paper that reports this interaction (PubMedID 14534299)
0

Data Source:
HPRD (in vitro)

		CCKBR	CCKAR
Description		cholecystokinin B receptor	cholecystokinin A receptor
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Cholecystokinin Receptor Activity Protein Binding Neuropeptide Receptor Activity Gastrin Receptor Activity Peptide Hormone Binding Type B Gastrin/cholecystokinin Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity	G Protein-coupled Receptor Activity Cholecystokinin Receptor Activity Peptide Hormone Binding
	Biological Process	Gastric Acid Secretion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Positive Regulation Of Cell Population Proliferation Cholecystokinin Signaling Pathway PH Reduction Digestive Tract Development Gland Development	Neuron Migration Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Axonogenesis Forebrain Development Cellular Response To Hormone Stimulus Cholecystokinin Signaling Pathway Regulation Of Hormone Secretion
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Pentagastrin Cholecystokinin	Ceruletide Dexloxiglumide Lintitript Cholecystokinin
Diseases
GWAS		Diastolic blood pressure ( 30224653) Early spontaneous preterm birth ( 31194736) Gastroesophageal reflux disease ( 31527586) Malaria ( 31844061) Rheumatic heart disease ( 34106200)
Interacting Genes		10 interacting genes: ADRB2 ATP13A2 CCK CCKAR CCR4 DRD2 NTM PPP1R9B PTPN11 SLCO1B3	3 interacting genes: CCK CCKBR PPP1R9B
Entrez ID		887	886
HPRD ID		00323	00322
Ensembl ID		ENSG00000110148	ENSG00000163394
Uniprot IDs		E9PIC8 P32239	P32238
PDB IDs		1L4T 7F8V 7F8W 7XOW 8IA7	1D6G 1HZN 7EZH 7EZK 7EZM 7F8U 7F8X 7F8Y 7MBX 7MBY 7XOU 7XOV 9BKJ 9BKK
Enriched GO Terms of Interacting Partners?		Cholecystokinin Signaling Pathway Axonogenesis Neuron Migration Cell Migration Neuron Projection Morphogenesis Cell Projection Morphogenesis Cell Motility Peptide Hormone Receptor Binding Regulation Of Growth Hormone Secretion Interneuron Migration G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Response To Morphine Regulation Of G Protein-coupled Receptor Signaling Pathway Multicellular Organismal-level Homeostasis Response To Amphetamine Temperature Homeostasis Cell Projection Organization Regulation Of Secretion By Cell Potassium Channel Regulator Activity Negative Regulation Of Blood Pressure Regulation Of Secretion Response To Nicotine Response To Amine Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Cellular Response To Epidermal Growth Factor Stimulus Smooth Muscle Contraction Vasodilation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Ossification Homeostatic Process Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of Hormone Secretion Positive Regulation Of Secretion By Cell Regulation Of Protein Secretion Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Response To Epidermal Growth Factor Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane Regulation Of Multicellular Organism Growth Positive Regulation Of Secretion Negative Regulation Of Hormone Secretion Regulation Of Sodium Ion Transport Forebrain Development	Cholecystokinin Signaling Pathway Type B Gastrin/cholecystokinin Receptor Binding Gastrin Receptor Activity Positive Regulation Of Ephrin Receptor Signaling Pathway Arterial Endothelial Cell Fate Commitment Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane Cholecystokinin Receptor Activity MAML1-RBP-Jkappa- ICN1 Complex Endocardium Morphogenesis Blood Vessel Endothelial Cell Fate Specification Blood Vessel Lumenization Auditory Receptor Cell Fate Commitment Regulation Of Cell Adhesion Involved In Heart Morphogenesis D2 Dopamine Receptor Binding Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Opioid Receptor Signaling Pathway Cellular Response To Morphine Club Cell Differentiation Epidermal Cell Fate Specification Pulmonary Valve Development Endothelial Cell Fate Specification Response To Kainic Acid Spine Apparatus 1-phosphatidylinositol-3-kinase Regulator Activity Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Aortic Valve Development Hair Follicle Maturation Endocardium Development Semi-lunar Valve Development Protein Localization To Actin Cytoskeleton Dendritic Spine Head Positive Regulation Of Protein Localization To Cell Cortex Response To L-phenylalanine Derivative Gland Development PH Reduction Positive Regulation Of Transcription Of Notch Receptor Target Male Mating Behavior Gastric Acid Secretion Sebaceous Gland Development Dorsal Aorta Morphogenesis Extrinsic Component Of Postsynaptic Membrane Cellular Response To Peptide Regulation Of Protein Localization To Cell Cortex Atrioventricular Canal Development Peptide Hormone Receptor Binding Cardiac Muscle Cell Myoblast Differentiation Secondary Heart Field Specification Cardiac Left Ventricle Morphogenesis
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