CCKBR and SLCO1B3

Number of citations of the paper that reports this interaction (PubMedID 10320330)
0

Data Source:
BioGRID (pull down)

		CCKBR	SLCO1B3
Description		cholecystokinin B receptor	solute carrier organic anion transporter family member 1B3
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Activity Cholecystokinin Receptor Activity Protein Binding Neuropeptide Receptor Activity Gastrin Receptor Activity Peptide Hormone Binding Type B Gastrin/cholecystokinin Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Serine-type Endopeptidase Inhibitor Activity Organic Anion Transmembrane Transporter Activity Bile Acid Transmembrane Transporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity Peptidase Inhibitor Activity
	Biological Process	Gastric Acid Secretion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Positive Regulation Of Cell Population Proliferation Cholecystokinin Signaling Pathway PH Reduction Digestive Tract Development Gland Development	Xenobiotic Metabolic Process Monoatomic Ion Transport Lipid Transport Organic Anion Transport Bile Acid And Bile Salt Transport Heme Catabolic Process Sodium-independent Organic Anion Transport Transmembrane Transport
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK	Recycling of bile acids and salts Heme degradation Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) Organic anion transport by SLCO transporters Atorvastatin ADME
Drugs		Pentagastrin Cholecystokinin	Clarithromycin Gemfibrozil Ginsenoside Rb1 Ginsenoside Rg1
Diseases
GWAS		Diastolic blood pressure ( 30224653) Early spontaneous preterm birth ( 31194736) Gastroesophageal reflux disease ( 31527586) Malaria ( 31844061) Rheumatic heart disease ( 34106200)	Alanine aminotransferase levels ( 34315874 33547301) Aspartate aminotransferase levels ( 34315874) Bilirubin levels ( 19419973 31801373 31319653 23371916 20639394) Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Height ( 18391951) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Parkinson's disease progression (cognitive) ( 33111402) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Total bilirubin levels ( 29403010)
Interacting Genes		10 interacting genes: ADRB2 ATP13A2 CCK CCKAR CCR4 DRD2 NTM PPP1R9B PTPN11 SLCO1B3	1 interacting genes: CCKBR
Entrez ID		887	28234
HPRD ID		00323	12021
Ensembl ID		ENSG00000110148	ENSG00000111700
Uniprot IDs		E9PIC8 P32239	B3KP78 Q9NPD5
PDB IDs		1L4T 7F8V 7F8W 7XOW 8IA7	8PG0
Enriched GO Terms of Interacting Partners?		Cholecystokinin Signaling Pathway Axonogenesis Neuron Migration Cell Migration Neuron Projection Morphogenesis Cell Projection Morphogenesis Cell Motility Peptide Hormone Receptor Binding Regulation Of Growth Hormone Secretion Interneuron Migration G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Response To Morphine Regulation Of G Protein-coupled Receptor Signaling Pathway Multicellular Organismal-level Homeostasis Response To Amphetamine Temperature Homeostasis Cell Projection Organization Regulation Of Secretion By Cell Potassium Channel Regulator Activity Negative Regulation Of Blood Pressure Regulation Of Secretion Response To Nicotine Response To Amine Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Cellular Response To Epidermal Growth Factor Stimulus Smooth Muscle Contraction Vasodilation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Ossification Homeostatic Process Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of Hormone Secretion Positive Regulation Of Secretion By Cell Regulation Of Protein Secretion Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Response To Epidermal Growth Factor Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane Regulation Of Multicellular Organism Growth Positive Regulation Of Secretion Negative Regulation Of Hormone Secretion Regulation Of Sodium Ion Transport Forebrain Development	Type B Gastrin/cholecystokinin Receptor Binding Gastrin Receptor Activity Cholecystokinin Receptor Activity Cholecystokinin Signaling Pathway Gastric Acid Secretion PH Reduction 1-phosphatidylinositol-3-kinase Regulator Activity Neuropeptide Receptor Activity Acid Secretion Peptide Hormone Binding Digestive Tract Development Digestive System Process Neuropeptide Signaling Pathway Regulation Of PH Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Tube Development Gland Development
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