CCKBR

Description		cholecystokinin B receptor
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GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	G Protein-coupled Receptor Activity Cholecystokinin Receptor Activity Protein Binding Neuropeptide Receptor Activity Gastrin Receptor Activity Peptide Hormone Binding Type B Gastrin/cholecystokinin Receptor Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Gastric Acid Secretion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Positive Regulation Of Cell Population Proliferation Cholecystokinin Signaling Pathway PH Reduction Digestive Tract Development Gland Development
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		Pentagastrin Cholecystokinin
Diseases
GWAS		Diastolic blood pressure ( 30224653) Early spontaneous preterm birth ( 31194736) Gastroesophageal reflux disease ( 31527586) Malaria ( 31844061) Rheumatic heart disease ( 34106200)
Interacting Genes		10 interacting genes: ADRB2 ATP13A2 CCK CCKAR CCR4 DRD2 NTM PPP1R9B PTPN11 SLCO1B3
Entrez ID		887
HPRD ID		00323
Ensembl ID		ENSG00000110148
Uniprot IDs		E9PIC8 P32239
PDB IDs		1L4T 7F8V 7F8W 7XOW 8IA7
Enriched GO Terms of Interacting Partners?		Cholecystokinin Signaling Pathway Axonogenesis Neuron Migration Cell Migration Neuron Projection Morphogenesis Cell Projection Morphogenesis Cell Motility Peptide Hormone Receptor Binding Regulation Of Growth Hormone Secretion Interneuron Migration G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Response To Morphine Regulation Of G Protein-coupled Receptor Signaling Pathway Multicellular Organismal-level Homeostasis Response To Amphetamine Temperature Homeostasis Cell Projection Organization Regulation Of Secretion By Cell Potassium Channel Regulator Activity Negative Regulation Of Blood Pressure Regulation Of Secretion Response To Nicotine Response To Amine Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Cellular Response To Epidermal Growth Factor Stimulus Smooth Muscle Contraction Vasodilation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Ossification Homeostatic Process Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of Hormone Secretion Positive Regulation Of Secretion By Cell Regulation Of Protein Secretion Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Response To Epidermal Growth Factor Spermine Transmembrane Transport ABC-type Polyamine Transporter Activity Positive Regulation Of Protein Localization To Actin Cortical Patch Dendritic Spine Neck Cytoplasmic Side Of Dendritic Spine Plasma Membrane Regulation Of Multicellular Organism Growth Positive Regulation Of Secretion Negative Regulation Of Hormone Secretion Regulation Of Sodium Ion Transport Forebrain Development
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