PER2 and CRY1

Number of citations of the paper that reports this interaction (PubMedID 11533252)
29

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vitro, in vivo, two hybrid)

		PER2	CRY1
Description		period circadian regulator 2	cryptochrome circadian regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm Cry-Per Complex	Nucleus Cytoplasm Mitochondrion
	Molecular Function	Transcription Cis-regulatory Region Binding Transcription Corepressor Binding Transcription Coactivator Activity Protein Binding	Nucleotide Binding DNA Binding Double-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Photoreceptor Activity Blue Light Photoreceptor Activity Nuclear Receptor Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Histone Deacetylase Binding E-box Binding FAD Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Ischemia Neural Retina Development Glycogen Biosynthetic Process Gluconeogenesis Chromatin Remodeling Fatty Acid Metabolic Process Circadian Rhythm Regulation Of Vasoconstriction Lactate Biosynthetic Process Negative Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Neurogenesis Regulation Of Insulin Secretion White Fat Cell Differentiation Regulation Of Cell Cycle Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Negative Regulation Of Fat Cell Proliferation Positive Regulation Of Cold-induced Thermogenesis	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Regulation Of Gluconeogenesis Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Lipid Storage Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Response To Insulin Circadian Regulation Of Gene Expression Response To Glucagon Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Signal Transduction In Response To DNA Damage Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Gluconeogenesis Positive Regulation Of Gluconeogenesis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of DNA Damage Checkpoint Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Glucocorticoid Secretion
Pathways		Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins Degradation of CRY and PER proteins	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins
Drugs
Diseases		Familial advanced sleep phase syndrome
GWAS		Chronotype ( 26955885 27494321 30696823) Morning vs. evening chronotype ( 26835600 26955885 27494321)	Morning person ( 30696823) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		20 interacting genes: BHLHE41 CLOCK CRY1 CRY2 CSNK1D CSNK1E CSNK2B DELEC1 ELOA LENG8 LMO4 MLH1 PER1 PER3 RORC TIMELESS TP53 TPT1 TPTEP2-CSNK1E UBL4A	25 interacting genes: ARIH1 BHLHE41 BMAL1 CBLB CLOCK CSNK1E DELEC1 GRN KRTAP4-12 LTBP4 MDFI NPAS2 NR1D2 PER1 PER2 PER3 PLSCR1 PPP2R1B PPP2R5D PPP2R5E SNRPD3 TIMELESS TRAF2 USP2 USP7
Entrez ID		8864	1407
HPRD ID		04575	09050
Ensembl ID		ENSG00000132326	ENSG00000008405
Uniprot IDs		O15055	A2I2P0 Q16526
PDB IDs		6OF7 8D7M 8D7N 8D7O
Enriched GO Terms of Interacting Partners?		Circadian Rhythm Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Rhythmic Process Photoperiodism Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Entrainment Of Circadian Clock Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription E-box Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Response To Light Stimulus Nucleus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Kinase Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Glucocorticoid Secretion Response To Radiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process DNA Damage Response Response To Blue Light Regulation Of Primary Metabolic Process Cellular Response To Radiation Photoreceptor Activity DNA-binding Transcription Factor Binding Negative Regulation Of Circadian Rhythm Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Thymocyte Apoptotic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Intracellular Signal Transduction Hematopoietic Or Lymphoid Organ Development Regulation Of Glucose Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Circadian Rhythm Regulation Of RNA Biosynthetic Process	Circadian Rhythm Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Rhythmic Process Photoperiodism CLOCK-BMAL Transcription Complex Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Redox State E-box Binding Protein Phosphatase Type 2A Complex Negative Regulation Of RNA Metabolic Process Circadian Behavior Nucleoplasm Rhythmic Behavior Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Hair Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Phosphatase Regulator Activity Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Corepressor Binding Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process Response To Light Stimulus Meiotic Sister Chromatid Cohesion Regulation Of RNA Metabolic Process Protein Dimerization Activity Negative Regulation Of Macromolecule Metabolic Process Chromatoid Body Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Membrane Raft Regulation Of Nucleobase-containing Compound Metabolic Process Protein Phosphatase Activator Activity Positive Regulation Of Circadian Rhythm Protein Stabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Response To Radiation Regulation Of Transcription By RNA Polymerase II Regulation Of Skeletal Muscle Cell Differentiation Transcription Cis-regulatory Region Binding
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