PER2 and PER3

Number of citations of the paper that reports this interaction (PubMedID 10837028)
35

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		PER2	PER3
Description		period circadian regulator 2	period circadian regulator 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm Cry-Per Complex	Nucleus Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding Transcription Corepressor Binding Transcription Coactivator Activity Protein Binding	Transcription Cis-regulatory Region Binding Transcription Corepressor Binding Protein Binding Kinase Binding Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Ischemia Neural Retina Development Glycogen Biosynthetic Process Gluconeogenesis Chromatin Remodeling Fatty Acid Metabolic Process Circadian Rhythm Regulation Of Vasoconstriction Lactate Biosynthetic Process Negative Regulation Of Protein Ubiquitination Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Neurogenesis Regulation Of Insulin Secretion White Fat Cell Differentiation Regulation Of Cell Cycle Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse Negative Regulation Of Fat Cell Proliferation Positive Regulation Of Cold-induced Thermogenesis	Negative Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Regulation Of Circadian Sleep/wake Cycle, Sleep Rhythmic Process Protein Stabilization
Pathways		Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins Degradation of CRY and PER proteins	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins Degradation of CRY and PER proteins
Drugs
Diseases		Familial advanced sleep phase syndrome
GWAS		Chronotype ( 26955885 27494321 30696823) Morning vs. evening chronotype ( 26835600 26955885 27494321)	Chronotype ( 30696823) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Ulcerative colitis ( 28067908)
Interacting Genes		20 interacting genes: BHLHE41 CLOCK CRY1 CRY2 CSNK1D CSNK1E CSNK2B DELEC1 ELOA LENG8 LMO4 MLH1 PER1 PER3 RORC TIMELESS TP53 TPT1 TPTEP2-CSNK1E UBL4A	9 interacting genes: BMAL1 CLOCK CRY1 CRY2 CSNK1D CSNK1E PER1 PER2 SP1
Entrez ID		8864	8863
HPRD ID		04575	09138
Ensembl ID		ENSG00000132326	ENSG00000049246
Uniprot IDs		O15055	A0A087WV69 A2I2N5 P56645
PDB IDs		6OF7 8D7M 8D7N 8D7O
Enriched GO Terms of Interacting Partners?		Circadian Rhythm Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Rhythmic Process Photoperiodism Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Entrainment Of Circadian Clock Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription E-box Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Response To Light Stimulus Nucleus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Kinase Binding Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Glucocorticoid Secretion Response To Radiation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process DNA Damage Response Response To Blue Light Regulation Of Primary Metabolic Process Cellular Response To Radiation Photoreceptor Activity DNA-binding Transcription Factor Binding Negative Regulation Of Circadian Rhythm Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Thymocyte Apoptotic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Non-canonical Wnt Signaling Pathway Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Intracellular Signal Transduction Hematopoietic Or Lymphoid Organ Development Regulation Of Glucose Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of Circadian Rhythm Regulation Of RNA Biosynthetic Process	Circadian Regulation Of Gene Expression Rhythmic Process Regulation Of Circadian Rhythm Circadian Rhythm Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Photoperiodism Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock E-box Binding Negative Regulation Of Circadian Rhythm Regulation Of Hormone Secretion Transcription Cis-regulatory Region Binding Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity Response To Light Stimulus Regulation Of Hair Cycle Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Cry-Per Complex Response To Radiation Negative Regulation Of Glucocorticoid Secretion CLOCK-BMAL Transcription Complex Regulation Of Hormone Levels Response To Blue Light Regulation Of Secretion By Cell Regulation Of Signal Transduction Regulation Of Secretion Regulation Of Type B Pancreatic Cell Development Regulation Of Gene Expression Photoreceptor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Negative Regulation Of RNA Biosynthetic Process Kinase Binding Positive Regulation Of Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Chromatoid Body Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Response To Redox State Positive Regulation Of Protein Metabolic Process Positive Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Cell Communication
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