PSMD10 and AGTR1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		PSMD10	AGTR1
Description		proteasome 26S subunit, non-ATPase 10	angiotensin II receptor type 1
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytoplasm Cytosol Cytoskeleton Cilium Proteasome Regulatory Particle, Base Subcomplex Microtubule Cytoskeleton	Plasma Membrane Membrane
	Molecular Function	Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Angiotensin Type I Receptor Activity G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Bradykinin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Apoptotic Process Positive Regulation Of Cell Growth Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Proteasome Regulatory Particle Assembly Negative Regulation Of Release Of Cytochrome C From Mitochondria	Regulation Of Cell Growth Kidney Development Renin-angiotensin Regulation Of Aldosterone Production Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Vasoconstriction Calcium-mediated Signaling Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Angiotensin-activated Signaling Pathway Regulation Of Cell Population Proliferation Symbiont Entry Into Host Cell Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Cell Chemotaxis Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Cholesterol Metabolic Process Blood Vessel Diameter Maintenance Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Proteasome assembly Proteasome assembly	Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Angiotensin II Candesartan
Diseases			Renal tubular dysgenesis
GWAS			Birth weight ( 31043758) Chin dimples ( 27182965) Height ( 31562340) Lead levels in blood ( 25820613) Monobrow ( 27182965) Type 2 diabetes ( 31049640)
Interacting Genes		17 interacting genes: AGTR1 CCND2 CDK4 CEBPA CLIC1 GRSF1 HSPA4 LDB1 MAGEA4 MDM2 NCK2 NFKB1 PSAT1 PSMC4 RB1 RELA UBC	77 interacting genes: ABI3 ACE2 ADD3 AGT AGTRAP AP2M1 ARFGAP1 ARHGDIG ARRB1 ARRB2 ATP13A1 ATP1B1 BAALC BASP1 BDKRB2 BNIP3 BRD8 CBR1 CCDC25 CD37 CERS6 CUEDC2 DBNDD2 DNAJC14 DNAJC8 EGFR FAM13B FBXW11 FNBP1 GHITM GNA12 GOT1 GPAA1 GPRASP1 GRK2 GRK3 GRK5 HDGFL2 HHATL HRAS JAK1 JAK2 JKAMP KIAA0930 LCNL1 LLGL1 LZTS1 NACAD NDRG2 NOS3 NPTN NUP88 OAZ1 PCMT1 PDE6H PLCG1 PLCH2 PNMA1 PPP1R3F PSMD10 PTGFR RAB5A RAF1 RBSN RTN3 SAE1 SCG5 SELENOF SERINC3 SLC16A1 SPG21 THOP1 TMEM161A TMEM80 UBR4 UGT8 YWHAQ
Entrez ID		5716	185
HPRD ID		04594	00107
Ensembl ID		ENSG00000101843	ENSG00000144891
Uniprot IDs		O75832	A0A0A0MSE3 D3DNG8 P30556 Q53YY0 Q6NUP5
PDB IDs		1QYM 1TR4 1UOH 4NIK 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 7VO6 7VXV 7VXW 7VY4 7VY7	4YAY 4ZUD 6DO1 6OS0 6OS1 6OS2
Enriched GO Terms of Interacting Partners?		Transcription Regulator Complex NF-kappaB P50/p65 Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mitotic Cell Cycle Phase Transition Cyclin D2-CDK4 Complex Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Response To Xenobiotic Stimulus Rb-E2F Complex Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Cellular Response To Peptide Hormone Stimulus Cellular Response To Nicotine Regulation Of Inflammatory Response Chromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA-templated Transcription Regulation Of Cell Differentiation Response To Vitamin Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA-templated Transcription Initiation Regulation Of Cell Population Proliferation Actinin Binding Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Process Cellular Response To Angiotensin Cellular Response To Interleukin-6 Negative Regulation Of Apoptotic Process Cellular Response To Tumor Necrosis Factor Negative Regulation Of Programmed Cell Death Positive Regulation Of Developmental Process Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cell Population Proliferation Response To Interleukin-6 Positive Regulation Of Proteasomal Protein Catabolic Process Ubiquitin Protein Ligase Binding Regulation Of Transcription By RNA Polymerase II Response To Peptide Hormone Response To Ether Response To Tumor Necrosis Factor Regulation Of Apoptotic Process Nucleoplasm Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Phase Transition Histone Deacetylase Binding	Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor Internalization Type 1 Angiotensin Receptor Binding G Protein-coupled Receptor Binding G Protein-coupled Receptor Kinase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Regulation Of Cell Communication Regulation Of Signaling Angiotensin Receptor Binding Endocytic Vesicle Membrane Membrane Type II Interferon-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Biological Quality Regulation Of Muscle System Process Regulation Of Protein Modification Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Blood Circulation Postsynaptic Density Negative Regulation Of Signal Transduction Establishment Of Protein Localization Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Endocytosis Regulation Of MAPK Cascade Regulation Of Vasoconstriction Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Receptor Internalization Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Gap Junction Assembly Interferon-mediated Signaling Pathway Plasma Membrane Clathrin-coated Pit Protein Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Phosphorylation Cytoplasm ERBB Signaling Pathway Import Into Cell Negative Regulation Of Apoptotic Process Tachykinin Receptor Signaling Pathway
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