AKAP4 and KDM6A

Data Source: HiPPIP (Novel)

		AKAP4	KDM6A
Name		A-kinase anchoring protein 4	lysine demethylase 6A
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoskeleton Cilium CAMP-dependent Protein Kinase Complex Z Disc Motile Cilium Sperm Fibrous Sheath Sperm Flagellum Cell Projection Perinuclear Region Of Cytoplasm Sperm Midpiece Sperm Principal Piece Sperm End Piece Sperm Head-tail Coupling Apparatus	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	Protein Binding Protein Kinase A Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3K27me2/H3K27me3 Demethylase Activity
	Biological Process	Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Single Fertilization Intracellular Protein Localization Cell Projection Organization Flagellated Sperm Motility Establishment Of Protein Localization Establishment Of Localization In Cell Sperm Flagellum Assembly	Chromatin Organization Chromatin Remodeling Heart Development Regulation Of Gene Expression
Pathways		None	HDMs demethylate histones Activation of anterior HOX genes in hindbrain development during early embryogenesis Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		1 novel interactors: KDM6A	7 novel interactors: AKAP4 BMP15 ELK1 HSD17B10 MAGED2 RBM3 ZNF157
Interacting Genes		6 interacting genes: AKAP3 FSIP1 FSIP2 PRKAR1A PRKAR2A PRKAR2B	15 interacting genes: CREBBP GSC2 H3-4 H3C1 H3C14 HUNK MEOX2 MTDH NKX2-5 RSPH1 SMAD9 SRF TBX5 TLE1 TSPYL2
Entrez ID		8852	7403
HPRD ID		02173	02131
Ensembl ID		ENSG00000147081	ENSG00000147050
Uniprot IDs		A0A384MQY7 Q5JQC9	A0A087X0R0 A0A6Q8PFK0 A0A804HJA2 B4E0L8 B7ZKN1 B7ZKN5 B7ZKN6 E1U0S6 F5H5V6 F5H6S1 F8W8R6 O15550 Q59HG3
PDB IDs		Not available	3AVR 3AVS 6FUK 6FUL
GO Terms Enriched among Interactors		CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Protein Kinase A Catalytic Subunit Binding CAMP Binding Negative Regulation Of CAMP/PKA Signal Transduction Ciliary Base Regulation Of CAMP/PKA Signal Transduction Nucleotide-activated Protein Kinase Complex Sperm Head-tail Coupling Apparatus Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Sperm Principal Piece Protein Domain Specific Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Raft Sperm Midpiece Ubiquitin Protein Ligase Binding Response To Antipsychotic Drug Axoneme Sperm Motility Flagellated Sperm Motility Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility Sperm End Piece Histone H3K27me2/H3K27me3 Demethylase Activity Centrosome Cilium Movement Negative Regulation Of Intracellular Signal Transduction G Protein-coupled Receptor Signaling Pathway Sperm Fibrous Sheath Cellular Response To Glucagon Stimulus Heart Development MLL3/4 Complex Negative Regulation Of Activated T Cell Proliferation Acrosome Reaction	RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin Atrioventricular Node Cell Fate Commitment Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus His-Purkinje System Cell Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Transcription Regulator Complex Nucleosome Assembly DNA-binding Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Chromatin Binding Regulation Of RNA Biosynthetic Process Nucleosome Organization Cardiocyte Differentiation Muscle Tissue Development Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Atrial Septum Development Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Cardiac Chamber Formation Protein-DNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Atrial Cardiac Muscle Tissue Development Ventricular Cardiac Muscle Tissue Development Regulation Of Primary Metabolic Process Muscle Cell Fate Commitment Heart Trabecula Formation Positive Regulation Of Cardiocyte Differentiation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cardiac Myofibril Assembly Structural Constituent Of Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Atrial Septum Morphogenesis Epithelium Development Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Regulation Of Metabolic Process Cellular Component Assembly Muscle Cell Differentiation Positive Regulation Of Stem Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process