PROM1 and HK2

Number of citations of the paper that reports this interaction (PubMedID 35975322)
64

Data Source:
BioGRID (pull down)

		PROM1	HK2
Description		prominin 1	hexokinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Microvillus Cilium Cell Surface Membrane Apical Plasma Membrane Microvillus Membrane Vesicle Photoreceptor Outer Segment Membrane Cell Projection Extracellular Exosome Prominosome	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Centrosome Cytosol Membrane Sarcoplasmic Reticulum
	Molecular Function	Protein Binding Cholesterol Binding Actinin Binding Cadherin Binding	Nucleotide Binding Catalytic Activity Glucokinase Activity Hexokinase Activity Protein Binding ATP Binding D-glucose Binding Fructokinase Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor
	Biological Process	Retina Layer Formation Photoreceptor Cell Maintenance Retina Morphogenesis In Camera-type Eye Camera-type Eye Photoreceptor Cell Differentiation Podocyte Differentiation Glomerular Parietal Epithelial Cell Differentiation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation	Response To Hypoxia Intracellular Glucose Homeostasis Response To Ischemia Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Glycolytic Process Lactation Apoptotic Mitochondrial Changes Hexose Metabolic Process Organophosphate Metabolic Process Negative Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Angiogenesis Regulation Of D-glucose Import Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Canonical Glycolysis Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Carbohydrate Derivative Metabolic Process Positive Regulation Of Type 2 Mitophagy Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Developmental Lineage of Pancreatic Ductal Cells	Glycolysis
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Stargardt disease (STGD); Fundus flavimaculatus Retinitis pigmentosa (RP) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Dental caries ( 23064961) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glomerular filtration rate in chronic kidney disease ( 26420894) Intracranial aneurysm ( 29531279) Pulse pressure ( 30224653) Self-rated health ( 20707712) Suicide attempts in depression or bipolar disorder ( 24964207)	Femoral neck bone geometry ( 22087292)
Interacting Genes		6 interacting genes: HDAC6 HK2 PIK3R1 PLEKHA5 SRC USP11	10 interacting genes: ENO1 MAGEA12 PRKCE PROM1 PTGDS SLC2A4 SUMO2 UBQLN1 UBQLN4 ZBTB17
Entrez ID		8842	3099
HPRD ID		05079	03080
Ensembl ID		ENSG00000007062	ENSG00000159399
Uniprot IDs		A0A0A0N0M1 O43490	E9PB90 P52789
PDB IDs			2NZT 5HEX 5HFU 5HG1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Type 2 Mitophagy Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Autophagy Of Mitochondrion Establishment Of Protein Localization To Organelle Regulation Of D-glucose Import Regulation Of Mitophagy Regulation Of Protein Stability Negative Regulation Of Cell-substrate Adhesion Cellular Response To Hormone Stimulus Negative Regulation Of Cell-matrix Adhesion Substrate Adhesion-dependent Cell Spreading Regulation Of Lamellipodium Organization Positive Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Organization Positive Regulation Of Epithelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Protein Destabilization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Transcription Corepressor Binding Regulation Of Epithelial Cell Migration Cellular Response To Hydrogen Peroxide Regulation Of D-glucose Transmembrane Transport Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell-substrate Junction Organization ERBB Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Caveola Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Intracellular Glucose Homeostasis Positive Regulation Of Macroautophagy Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Protein Localization To Nucleus Protein Deubiquitination Response To Hydrogen Peroxide Positive Regulation Of Catabolic Process Positive Regulation Of Cell Migration Protein Modification By Small Protein Removal Cellular Response To Reactive Oxygen Species Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Tubulin Deacetylase Activity Positive Regulation Of Cell Motility Positive Regulation Of Locomotion	Regulation Of Proteolysis Cellular Response To Decreased Oxygen Levels Cellular Response To Hypoxia Perinuclear Region Of Cytoplasm Cellular Response To Oxygen Levels Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Response To Hypoxia Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Negative Regulation Of Store-operated Calcium Channel Activity Response To Decreased Oxygen Levels Regulation Of Protein Metabolic Process Response To Oxygen Levels Endoplasmic Reticulum Negative Regulation Of Cation Transmembrane Transport Ethanol Binding Negative Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Brain-derived Neurotrophic Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Prominosome Glomerular Parietal Epithelial Cell Differentiation Autophagosome Nuclear Proteasome Complex Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Negative Regulation Of Monoatomic Ion Transport TRAM-dependent Toll-like Receptor 4 Signaling Pathway Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation Negative Regulation Of Transmembrane Transport Positive Regulation Of Proteasomal Protein Catabolic Process Response To Ethanol Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Toxin Catabolic Process White Fat Cell Proliferation Positive Regulation Of Mucus Secretion Regulation Of Male Germ Cell Proliferation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cytosolic Proteasome Complex Regulation Of Cellular Response To Stress Regulation Of Calcium Ion Transmembrane Transport Positive Regulation Of Catabolic Process Regulation Of Germ Cell Proliferation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?