PROM1

Description		prominin 1
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Microvillus Cilium Cell Surface Membrane Apical Plasma Membrane Microvillus Membrane Vesicle Photoreceptor Outer Segment Membrane Cell Projection Extracellular Exosome Prominosome
	Molecular Function	Protein Binding Cholesterol Binding Actinin Binding Cadherin Binding
	Biological Process	Retina Layer Formation Photoreceptor Cell Maintenance Retina Morphogenesis In Camera-type Eye Camera-type Eye Photoreceptor Cell Differentiation Podocyte Differentiation Glomerular Parietal Epithelial Cell Differentiation Positive Regulation Of Nephron Tubule Epithelial Cell Differentiation
Pathways		Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Stargardt disease (STGD); Fundus flavimaculatus Retinitis pigmentosa (RP) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Dental caries ( 23064961) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glomerular filtration rate in chronic kidney disease ( 26420894) Intracranial aneurysm ( 29531279) Pulse pressure ( 30224653) Self-rated health ( 20707712) Suicide attempts in depression or bipolar disorder ( 24964207)
Interacting Genes		6 interacting genes: HDAC6 HK2 PIK3R1 PLEKHA5 SRC USP11
Entrez ID		8842
HPRD ID		05079
Ensembl ID		ENSG00000007062
Uniprot IDs		A0A0A0N0M1 O43490
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Type 2 Mitophagy Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Autophagy Of Mitochondrion Establishment Of Protein Localization To Organelle Regulation Of D-glucose Import Regulation Of Mitophagy Regulation Of Protein Stability Negative Regulation Of Cell-substrate Adhesion Cellular Response To Hormone Stimulus Negative Regulation Of Cell-matrix Adhesion Substrate Adhesion-dependent Cell Spreading Regulation Of Lamellipodium Organization Positive Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Organization Positive Regulation Of Epithelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Protein Destabilization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Transcription Corepressor Binding Regulation Of Epithelial Cell Migration Cellular Response To Hydrogen Peroxide Regulation Of D-glucose Transmembrane Transport Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell-substrate Junction Organization ERBB Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Caveola Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Intracellular Glucose Homeostasis Positive Regulation Of Macroautophagy Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Protein Localization To Nucleus Protein Deubiquitination Response To Hydrogen Peroxide Positive Regulation Of Catabolic Process Positive Regulation Of Cell Migration Protein Modification By Small Protein Removal Cellular Response To Reactive Oxygen Species Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Tubulin Deacetylase Activity Positive Regulation Of Cell Motility Positive Regulation Of Locomotion
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